Air− liquid Interface cultures of the healthy and diseased human respiratory tract: promises, challenges, and future directions
D Baldassi, B Gabold, OM Merkel - Advanced nanobiomed …, 2021 - Wiley Online Library
Air− liquid interface (ALI) culture models currently represent a valid instrument to recreate
the typical aspects of the respiratory tract in vitro in both healthy and diseased state. They …
the typical aspects of the respiratory tract in vitro in both healthy and diseased state. They …
[HTML][HTML] Air-liquid interface (ALI) impact on different respiratory cell cultures
The intranasal route has been receiving greater attention from the scientific community not
only for systemic drug delivery but also for the treatment of pulmonary and neurological …
only for systemic drug delivery but also for the treatment of pulmonary and neurological …
Characterization of the COPD alveolar niche using single-cell RNA sequencing
Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide,
however our understanding of cell specific mechanisms underlying COPD pathobiology …
however our understanding of cell specific mechanisms underlying COPD pathobiology …
A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection
F Humphries, L Shmuel-Galia, Z Jiang, R Wilson… - Science …, 2021 - science.org
Coronaviruses are a family of RNA viruses that cause acute and chronic diseases of the
upper and lower respiratory tract in humans and other animals. Severe acute respiratory …
upper and lower respiratory tract in humans and other animals. Severe acute respiratory …
SARS-CoV-2 infection of pluripotent stem cell-derived human lung alveolar type 2 cells elicits a rapid epithelial-intrinsic inflammatory response
A hallmark of severe COVID-19 pneumonia is SARS-CoV-2 infection of the facultative
progenitors of lung alveoli, the alveolar epithelial type 2 cells (AT2s). However, inability to …
progenitors of lung alveoli, the alveolar epithelial type 2 cells (AT2s). However, inability to …
In vitro and in vivo models for studying SARS-CoV-2, the etiological agent responsible for COVID-19 pandemic
RB Rosa, WM Dantas, JCF do Nascimento… - Viruses, 2021 - mdpi.com
The emergence and rapid worldwide spread of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has prompted the scientific community to rapidly develop in …
coronavirus 2 (SARS-CoV-2) has prompted the scientific community to rapidly develop in …
Rapid endotheliitis and vascular damage characterize SARS‐CoV‐2 infection in a human lung‐on‐chip model
Severe cases of SARS‐CoV‐2 infection are characterized by hypercoagulopathies and
systemic endotheliitis of the lung microvasculature. The dynamics of vascular damage, and …
systemic endotheliitis of the lung microvasculature. The dynamics of vascular damage, and …
Harnessing organs-on-a-chip to model tissue regeneration
Tissue engineering has markedly matured since its early beginnings in the 1980s. In
addition to the original goal to regenerate damaged organs, the field has started to explore …
addition to the original goal to regenerate damaged organs, the field has started to explore …
[HTML][HTML] Alveolar type II cells and pulmonary surfactant in COVID-19 era
A Calkovska, M Kolomaznik, V Calkovsky - Physiological research, 2021 - ncbi.nlm.nih.gov
In this review, we discuss the role of pulmonary surfactant in the host defense against
respiratory pathogens, including novel coronavirus SARS-CoV-2. In the lower respiratory …
respiratory pathogens, including novel coronavirus SARS-CoV-2. In the lower respiratory …
[HTML][HTML] Culture impact on the transcriptomic programs of primary and iPSC-derived human alveolar type 2 cells
Dysfunction of alveolar epithelial type 2 cells (AEC2s), the facultative progenitors of lung
alveoli, is implicated in pulmonary disease pathogenesis, highlighting the importance of …
alveoli, is implicated in pulmonary disease pathogenesis, highlighting the importance of …