Mitochondrial calcium exchange in physiology and disease
JF Garbincius, JW Elrod - Physiological reviews, 2022 - journals.physiology.org
The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …
fundamental biological process that has critical effects on cellular metabolism, signaling …
The machineries, regulation and cellular functions of mitochondrial calcium
Abstract Calcium ions (Ca2+) are some of the most versatile signalling molecules, and they
have many physiological functions, prominently including muscle contraction, neuronal …
have many physiological functions, prominently including muscle contraction, neuronal …
Calcium dynamics as a machine for decoding signals
Calcium (Ca 2+) is considered one of the most-important biological cations, because it is
implicated in cell physiopathology and cell fate through a finely tuned signaling system. In …
implicated in cell physiopathology and cell fate through a finely tuned signaling system. In …
[HTML][HTML] Mitochondrial calcium transport and the redox nature of the calcium-induced membrane permeability transition
Mitochondria possess a Ca 2+ transport system composed of separate Ca 2+ influx and
efflux pathways. Intramitochondrial Ca 2+ concentrations regulate oxidative …
efflux pathways. Intramitochondrial Ca 2+ concentrations regulate oxidative …
MCU proteins dominate in vivo mitochondrial Ca2+ uptake in Arabidopsis roots
Ca2+ signaling is central to plant development and acclimation. While Ca2+-responsive
proteins have been investigated intensely in plants, only a few Ca2+-permeable channels …
proteins have been investigated intensely in plants, only a few Ca2+-permeable channels …
Rapid, selection-free, high-efficiency genome editing in protozoan parasites using CRISPR-Cas9 ribonucleoproteins
Trypanosomatids (order Kinetoplastida), including the human pathogens Trypanosoma cruzi
(agent of Chagas disease), Trypanosoma brucei,(African sleeping sickness), and …
(agent of Chagas disease), Trypanosoma brucei,(African sleeping sickness), and …
MCUb induction protects the heart from postischemic remodeling
Rationale: Mitochondrial Ca2+ loading augments oxidative metabolism to match functional
demands during times of increased work or injury. However, mitochondrial Ca2+ overload …
demands during times of increased work or injury. However, mitochondrial Ca2+ overload …
[HTML][HTML] Recent advances in the molecular mechanism of mitochondrial calcium uptake
In the last few decades, a large body of experimental evidence has highlighted the complex
role for mitochondria in eukaryotic cells: they are not only the site of aerobic metabolism …
role for mitochondria in eukaryotic cells: they are not only the site of aerobic metabolism …
IP3 receptor-mediated Ca2+ release from acidocalcisomes regulates mitochondrial bioenergetics and prevents autophagy in Trypanosoma cruzi
In contrast to animal cells, the inositol 1, 4, 5-trisphosphate receptor of Trypanosoma cruzi
(TcIP 3 R) localizes to acidocalcisomes instead of the endoplasmic reticulum. Here, we …
(TcIP 3 R) localizes to acidocalcisomes instead of the endoplasmic reticulum. Here, we …
From the identification to the dissection of the physiological role of the mitochondrial calcium uniporter: an ongoing story
The notion of mitochondria being involved in the decoding and shaping of intracellular Ca2+
signals has been circulating since the end of the 19th century. Despite that, the molecular …
signals has been circulating since the end of the 19th century. Despite that, the molecular …