Carbohydrate-carrying molecules in the nervous system have important roles during
development, regeneration and synaptic plasticity. Carbohydrates mediate interactions …

Interactions between cells and the extracellular matrix (ECM) have long been accepted to
have pivotal roles in neural development and regeneration. Recent data also support the …

Glycan structures covalently attached to proteins and lipids play numerous roles in
mammalian cells, including protein folding, targeting, recognition, and adhesion at the …

O-sulfogalactosylceramide or sulfatide is a major component of the myelin sheath in the
central and peripheral nervous system. The examination of mice deficient in the sulfatide …

Recent studies have explored the function of N-linked glycosylation in the nervous system,
demonstrating essential roles of carbohydrate structures in neural development. The …

Carbohydrates play a central role in a wide range of biological processes. As with nucleic
acids and proteins, modifications of specific sites within the glycan chain can modulate a …

Neural extracellular matrix (ECM) molecules derived from neurons and glial cells
accumulate in the extracellular space and regulate synaptic plasticity through modulation of …

Aggrecan, a chondroitin sulfate (CS) proteoglycan, forms lattice-like extracellular matrix
structures called perineuronal nets (PNNs). Neocortical PNNs primarily ensheath …

Objective: Sulfate (SO42−) is an abundant component of intestinal mucins and its content is
decreased in certain gastrointestinal diseases, including inflammatory bowel disease. In this …

Protein N-glycosylation can influence the nervous system in a variety of ways by affecting
functions of glycoproteins involved in nervous system development and physiology. The …