Succinate is an important metabolite at the cross-road of several metabolic pathways, also
involved in the formation and elimination of reactive oxygen species. However, it is …

The renin-angiotensin system has powerful effects in control of the blood pressure and
sodium homeostasis. These actions are coordinated through integrated actions in the …

Succinate is a signaling metabolite sensed extracellularly by succinate receptor 1
(SUNCR1). The accumulation of succinate in macrophages is known to activate a pro …

Abstract SUCNR1 (or GPR91) belongs to the family of G protein-coupled receptors (GPCR),
which represents the largest group of membrane proteins in human genome. The majority of …

Studies over the past decade have highlighted important roles played by sensory receptors
outside of traditionally sensory tissues; for example, taste receptors participate in pH sensing …

Diabetes normally causes lipid accumulation and oxidative stress in the kidneys, which
plays a critical role in the onset of diabetic nephropathy; however, the mechanism by which …

Salt sensitive hypertension is characterized by increases in blood pressure in response to
increases in dietary salt intake and is associated with an enhanced risk of cardiovascular …

Recent studies have provided further evidence for the presence of many components of the
RAS in glomerular structures, which supports the importance of locally produced …

A limited number of pulmonary pathogens are able to evade normal mucosal defenses to
establish acute infection and then adapt to cause chronic pneumonias. Pathogens, such as …

Background and Purpose The succinate receptor (formerly GPR91 or SUCNR1) is
described as a metabolic sensor that may be involved in homeostasis. Notwithstanding its …