Airway structure and function are key aspects of normal lung development, growth, and
aging, as well as of lung responses to the environment and the pathophysiology of important …

Aging is a major risk factor for the leading causes of mortality, and the incidence of age-
related diseases including cardiovascular disease, kidney disease and metabolic disease …

Metabolomics, the quantification of small biochemicals in plasma and tissues, can provide
insight into complex biochemical processes and enable the identification of biomarkers that …

CD38 is the main enzyme for nicotinamide adenine dinucleotide (NAD) degradation in
mammalian cells. Decreased NAD levels are closely related to metabolic syndromes and …

Duchenne muscular dystrophy (DMD) is characterized by progressive muscle degeneration.
Two important deleterious features are a Ca2+ dysregulation linked to Ca2+ influxes …

Diseases such as asthma are exacerbated by inflammation, cigarette smoke and even
nicotine delivery devices such as e-cigarettes. However, there is currently little information …

Duchenne muscular dystrophy (DMD) is a lethal degenerative muscle wasting disease
caused by the loss of the structural protein dystrophin with secondary pathological …

The various roles of microRNAs (miRNAs) in the epigenetic regulation of human disease are
gaining importance as areas of research, and a better understanding of these roles may …

Brain-derived neurotrophic factor (BDNF), a neurotrophin produced by airway smooth
muscle (ASM), enhances inflammation effects on airway contractility, supporting the idea …

CD38 is an ectoenzyme that catalyzes the conversion of β-nicotinamide adenine
dinucleotide (β-NAD) to cyclic adenosine diphosphoribose (cADPR) and adenosine …