In the past five years, skeletal muscle has emerged as a paradigm of “nitric oxide”(NO)
function and redox-related signaling in biology. All major nitric oxide synthase (NOS) …

Nitric oxide synthase (NOS) exists in three established isoforms. NOS I (NOS1, ncNOS) was
originally discovered in neurons. This enzyme and splice variants thereof have since been …

Endogenous nitric oxide (NO) mediates certain aspects of synaptic plasticity and
neurotoxicity associated with NMDA-type glutamate receptors. Neuronal NO synthase …

The accumulation of covalently modified proteins is an important hallmark of biological
aging, but relatively few studies have addressed the detailed molecular-chemical changes …

Null mutation of any one of several members of the dystrophin protein complex can cause
progressive, and possibly fatal, muscle wasting. Although these muscular dystrophies arise …

The neuromuscular junction (NMJ) is a complex structure that serves to efficiently
communicate the electrical impulse from the motor neuron to the skeletal muscle to signal …

Cyclic GMP is a widely distributed second messenger which was discovered more than 30
years ago. Cyclic GMP is synthesized by soluble and particulate guanylyl cydases and is …

Skeletal muscle and myocardium express μNOS I, an elongated splice variant of neuronal-
type nitric oxide (NO) synthase (NOS I), and NOS III, endothelial-type NO synthase …

A possible treatment for Duchenne muscular dystrophies would be to compensate for
dystrophin loss by increasing the expression of utrophin, another cytoskeletal protein of the …

The present review deals with the anatomical distribution, physiological importance, and
pathological implications of the neuronal-type nitric oxide synthase (nNOS) in skeletal …