Multiple endocrine neoplasia type 2: A review

JS Mathiesen, G Effraimidis, M Rossing… - Seminars in cancer …, 2022 - Elsevier
Multiple endocrine neoplasias are rare hereditary syndromes some of them with malignant
potential. Multiple endocrine neoplasia type 2 (MEN 2) is an autosomal dominant hereditary …

[HTML][HTML] Diagnostic, prognostic, and predictive role of Ki67 proliferative index in neuroendocrine and endocrine neoplasms: past, present, and future

S La Rosa - Endocrine Pathology, 2023 - Springer
The introduction of Ki67 immunohistochemistry in the work-up of neuroendocrine neoplasms
(NENs) has opened a new approach for their diagnosis and prognostic evaluation. Since the …

[HTML][HTML] Sporadic medullary thyroid carcinoma: towards a precision medicine

A Matrone, C Gambale, A Prete, R Elisei - Frontiers in endocrinology, 2022 - frontiersin.org
Medullary thyroid carcinoma (MTC) is a neuroendocrine malignant tumor originating from
parafollicular C-cells producing calcitonin. Most of cases (75%) are sporadic while the …

Predicting outcomes in sporadic and hereditary medullary thyroid carcinoma over two decades

A Kotwal, D Erickson, JR Geske, ID Hay, MR Castro - Thyroid, 2021 - liebertpub.com
Background: Medullary thyroid cancer (MTC) can be associated with significant morbidity
and mortality in advanced cases. Hence, we aimed to identify factors at the time of MTC …

Prediction of biochemical cure in patients with medullary thyroid cancer

A Machens, K Lorenz, H Dralle - Journal of British Surgery, 2020 - academic.oup.com
Background The impact of number of node metastases versus metastatic lymph node ratio
versus AJCC node category on biochemical cure in medullary thyroid cancer (MTC) is not …

Management of medullary thyroid cancer: patterns of recurrence and outcomes of reoperative surgery

AJ Papachristos, LE Nicholls, R Mechera… - The …, 2023 - academic.oup.com
Background There remains uncertainty regarding the optimal extent of initial surgery and
management of recurrent disease in medullary thyroid cancer (MTC). We aim to describe the …

[HTML][HTML] Update on preclinical development and clinical translation of cholecystokinin-2 receptor targeting radiopharmaceuticals

E von Guggenberg, P Kolenc, C Rottenburger… - Cancers, 2021 - mdpi.com
Simple Summary Peptide analogs, derived from the natural peptide hormone gastrin, are
promising candidates for improving the visualization and treatment of tumors. Gastrin …

Association between programmed death-ligand 1 expression and clinicopathological characteristics, structural recurrence, and biochemical recurrence/persistent …

X Shi, PC Yu, BW Lei, CW Li, Y Zhang, LC Tan, RL Shi… - Thyroid, 2019 - liebertpub.com
Background: Expression of the programmed death-ligand 1 (PD-L1) in medullary thyroid
carcinoma (MTC) has been rarely reported. In this study, we evaluated PD-L1 positivity in …

[HTML][HTML] Multimodal imaging of thyroid cancer

K Brauckhoff, M Biermann - Current Opinion in Endocrinology …, 2020 - journals.lww.com
The mainstay of diagnosing thyroid cancer is thyroid ultrasound with ultrasound-guided
FNB. Contrast-enhanced computed tomography and PET with [18 F]-fluorodeoxyglucose …

Update on C-cell neuroendocrine neoplasm: prognostic and predictive histopathologic and molecular features of medullary thyroid carcinoma

CK Jung, S Agarwal, JF Hang, DJ Lim, A Bychkov… - Endocrine …, 2023 - Springer
Medullary thyroid carcinoma (MTC) is a C-cell-derived epithelial neuroendocrine neoplasm.
With the exception of rare examples, most are well-differentiated epithelial neuroendocrine …