Focal-adhesion kinase (FAK) is an important mediator of growth-factor signalling, cell
proliferation, cell survival and cell migration. Given that the development of malignancy is …

The calpains are a conserved family of cysteine proteinases that catalyse the controlled
proteolysis of many specific substrates. Calpain activity is implicated in several fundamental …

Dynamic regulation of adhesion complexes is required for cell migration and has therefore
emerged as a key issue in the study of cell motility. Recent progress has been made in …

The calpain family of proteases has been implicated in cellular processes such as
apoptosis, proliferation and cell migration. Calpains are involved in several key aspects of …

Integrin endocytic recycling is critical for cell migration, yet how recycled integrins assemble
into new adhesions is unclear. By synchronizing endocytic disassembly of focal adhesions …

The coordinated and dynamic regulation of adhesions is required for cell migration. We
demonstrated previously that limited proteolysis of talin1 by the calcium-dependent protease …

Invasive cancer cells form dynamic adhesive structures associated with matrix degradation
called invadopodia. Calpain 2 is a calcium-dependent intracellular protease that regulates …

Calpains are intracellular nonlysosomal Ca2+-regulated cysteine proteases. They mediate
regulatory cleavages of specific substrates in a large number of processes during the …

The integrin family of extracellular matrix receptors regulates many aspects of cell life, in
particular cell adhesion and migration. These two processes depend on organization of the …

The actin cross-linking protein filamin A (FLNa) functions as a scaffolding protein and
couples cell cytoskeleton to extracellular matrix and integrin receptor signaling. In this study …