Regulation of SIRT1 and its roles in inflammation
Y Yang, Y Liu, Y Wang, Y Chao, J Zhang, Y Jia… - Frontiers in …, 2022 - frontiersin.org
The silent information regulator sirtuin 1 (SIRT1) protein, a highly conserved NAD+-
dependent deacetylase belonging to the sirtuin family, is a post-translational regulator that …
dependent deacetylase belonging to the sirtuin family, is a post-translational regulator that …
[HTML][HTML] Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment
In recent decades, chemotherapies targeting apoptosis have emerged and demonstrated
remarkable achievements. However, emerging evidence has shown that chemoresistance is …
remarkable achievements. However, emerging evidence has shown that chemoresistance is …
The beneficial roles of SIRT1 in neuroinflammation‐related diseases
F Jiao, Z Gong - Oxidative medicine and cellular longevity, 2020 - Wiley Online Library
Sirtuins are the class III of histone deacetylases whose deacetylate of histones is dependent
on nicotinamide adenine dinucleotide (NAD+). Among seven sirtuins, SIRT1 plays a critical …
on nicotinamide adenine dinucleotide (NAD+). Among seven sirtuins, SIRT1 plays a critical …
Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer
Background The TP53 gene is one of the most commonly inactivated tumor suppressors in
human cancers. p53 functions during cancer progression have been linked to a variety of …
human cancers. p53 functions during cancer progression have been linked to a variety of …
The role of SIRT1 on DNA damage response and epigenetic alterations in cancer
DK Alves-Fernandes, MG Jasiulionis - International journal of molecular …, 2019 - mdpi.com
Sirtuin-1 (SIRT1) is a class-III histone deacetylase (HDAC), an NAD+-dependent enzyme
deeply involved in gene regulation, genome stability maintenance, apoptosis, autophagy …
deeply involved in gene regulation, genome stability maintenance, apoptosis, autophagy …
Ferroptosis: a new regulatory mechanism in osteoporosis
P Liu, W Wang, Z Li, Y Li, X Yu, J Tu… - Oxidative Medicine and …, 2022 - Wiley Online Library
Osteoporosis can be caused by a multitude of factors and is defined by a decrease in bone
density and mass caused by the destruction of bone microstructure, resulting in increased …
density and mass caused by the destruction of bone microstructure, resulting in increased …
Therapeutic targets for DOX-induced cardiomyopathy: role of apoptosis vs. ferroptosis
H Kitakata, J Endo, H Ikura, H Moriyama… - International journal of …, 2022 - mdpi.com
Doxorubicin (DOX) is the most widely used anthracycline anticancer agent; however, its
cardiotoxicity limits its clinical efficacy. Numerous studies have elucidated the mechanisms …
cardiotoxicity limits its clinical efficacy. Numerous studies have elucidated the mechanisms …
[HTML][HTML] SIRT1 is a regulator of autophagy: Implications for the progression and treatment of myocardial ischemia-reperfusion
X Ding, C Zhu, W Wang, M Li, C Ma, B Gao - Pharmacological research, 2024 - Elsevier
SIRT1 is a highly conserved nicotinamide adenine dinucleotide (NAD+)-dependent histone
deacetylase. It is involved in the regulation of various pathophysiological processes …
deacetylase. It is involved in the regulation of various pathophysiological processes …
Emerging role of aging in the progression of NAFLD to HCC
Y He, Y Su, C Duan, S Wang, W He, Y Zhang… - Ageing Research …, 2023 - Elsevier
With the aging of global population, the incidence of nonalcoholic fatty liver disease
(NAFLD) has surged in recent decades. NAFLD is a multifactorial disease that follows a …
(NAFLD) has surged in recent decades. NAFLD is a multifactorial disease that follows a …
Relevance of SIRT1-NF-κB axis as therapeutic target to ameliorate inflammation in liver disease
Inflammation is an adaptive response in pursuit of homeostasis reestablishment triggered by
harmful conditions or stimuli, such as an infection or tissue damage. Liver diseases cause …
harmful conditions or stimuli, such as an infection or tissue damage. Liver diseases cause …