Tau post-translational modifications: dynamic transformers of tau function, degradation, and aggregation
C Alquezar, S Arya, AW Kao - Frontiers in neurology, 2021 - frontiersin.org
Post-translational modifications (PTMs) on tau have long been recognized as affecting
protein function and contributing to neurodegeneration. The explosion of information on …
protein function and contributing to neurodegeneration. The explosion of information on …
Nutrient regulation of signaling and transcription
GW Hart - Journal of Biological Chemistry, 2019 - ASBMB
In the early 1980s, while using purified glycosyltransferases to probe glycan structures on
surfaces of living cells in the murine immune system, we discovered a novel form of …
surfaces of living cells in the murine immune system, we discovered a novel form of …
Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease
O-GlcNAcylation is the addition of β-DN-acetylglucosamine to serine or threonine residues
of nuclear and cytoplasmic proteins. O-linked N-acetylglucosamine (O-GlcNAc) was not …
of nuclear and cytoplasmic proteins. O-linked N-acetylglucosamine (O-GlcNAc) was not …
Cycling of O-linked β-N-acetylglucosamine on nucleocytoplasmic proteins
All animals and plants dynamically attach and remove O-linked β-N-acetylglucosamine (O-
GlcNAc) at serine and threonine residues on myriad nuclear and cytoplasmic proteins. O …
GlcNAc) at serine and threonine residues on myriad nuclear and cytoplasmic proteins. O …
Demystifying the O-GlcNAc code: a systems view
Post-translational modification with O-linked β-N-acetylglucosamine (O-GlcNAc), a process
referred to as O-GlcNAcylation, occurs on a vast variety of proteins. Mounting evidence in …
referred to as O-GlcNAcylation, occurs on a vast variety of proteins. Mounting evidence in …
A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo
SA Yuzwa, MS Macauley, JE Heinonen, X Shan… - Nature chemical …, 2008 - nature.com
Pathological hyperphosphorylation of the microtubule-associated protein tau is
characteristic of Alzheimer's disease (AD) and the associated tauopathies. The reciprocal …
characteristic of Alzheimer's disease (AD) and the associated tauopathies. The reciprocal …
Glycosylation of nucleocytoplasmic proteins: signal transduction and O-GlcNAc
The dynamic glycosylation of serine or threonine residues on nuclear and cytosolic proteins
by O-linked β-N-acetylglucosamine (O-GlcNAc) is abundant in all multicellular eukaryotes …
by O-linked β-N-acetylglucosamine (O-GlcNAc) is abundant in all multicellular eukaryotes …
Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic β-N-acetylglucosaminidase from human brain
Dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine
(O-GlcNAc) on Ser/Thr residues is ubiquitous in higher eukaryotes and is analogous to …
(O-GlcNAc) on Ser/Thr residues is ubiquitous in higher eukaryotes and is analogous to …
Dynamic O-GlcNAc modification of nucleocytoplasmic proteins in response to stress: a survival response of mammalian cells
NE Zachara, N O'Donnell, WD Cheung… - Journal of Biological …, 2004 - ASBMB
Cellular response to environmental, physiological, or chemical stress is key to survival
following injury or disease. Here we describe a unique signaling mechanism by which cells …
following injury or disease. Here we describe a unique signaling mechanism by which cells …
Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability
Post-translational addition of O-linked N-acetylglucosamine (O-GlcNAc) to p53 is known to
occur, but the site of O-GlcNAcylation and its effects on p53 are not understood. Here, we …
occur, but the site of O-GlcNAcylation and its effects on p53 are not understood. Here, we …