Lipid composition determines membrane properties, and cholesterol plays a major role in
this determination as it regulates membrane fluidity and permeability, as well as induces the …

Cholesterol (Chol) is an essential component of animal cell membranes and is most
abundant in plasma membranes (PMs) where its concentration typically ranges from 10 to …

Several discoveries show that with age and cataract formation, β-crystallin binds with the
lens membrane or associates with other lens proteins, which bind with the fiber cell plasma …

This study addresses the question: why do rats get cataracts at 2 years, dogs at 8 years, and
whales do not develop cataracts for 200 years? Whale lens lipid phase transitions were …

Cholesterol (Chol) content in most cellular membranes does not exceed 50 mol%, only in
the eye lens's fiber cell plasma membrane, its content surpasses 50 mol%. At this high …

α-crystallin is a major protein found in the mammalian eye lens that works as a molecular
chaperone by preventing the aggregation of proteins and providing tolerance to stress in the …

Purpose This research aims to probe the interaction of α-crystallin with a model of human,
porcine, and mouse lens-lipid membranes. Methods Cholesterol/model of human lens-lipid …

The plasma membranes of the human lens fiber cell are overloaded with cholesterol that not
only saturates the phospholipid bilayer of these membranes but also leads to the formation …

The most unique biochemical characteristic of the eye lens fiber cell plasma membrane is its
extremely high cholesterol content, the need for which is still unclear. It is evident, however …

It is well-studied that the significant factor in cataract formation is the association of α-
crystallin, a major eye lens protein, with the fiber cell plasma membrane of the eye lens. The …