Hypoxia is a common feature of malignant tumors. There is an interactive connection
between hypoxia and chemoresistance, radioresistance, invasiveness, and angiogenesis …

A tumor‐specific microenvironment is characterized by hypoxia, in which oxygen tension is
considerably lower than in normal tissues. The hypoxic status of various solid tumors has …

Oxygen imaging of biological cells and tissues is becoming increasingly important in cell
biology and in the pathophysiology of various hypoxia-related diseases. The optical oxygen …

Human solid tumors contain hypoxic regions that have considerably lower oxygen tension
than the normal tissues. Hypoxia offers resistance to radiotherapy and anticancer …

There is a need to measure tumor hypoxia in assessing the aggressiveness of tumor and
predicting the outcome of therapy. A number of invasive and noninvasive techniques have …

Solid tumors possess unique microenvironments that are exposed to chronic hypoxic
conditions, so-called tumor hypoxia. Although more than half a century has passed since it …

Purpose: Pancreatic cancer is characterized by intratumoral hypoxia, early and aggressive
local invasion, and metastatic potential. Hypoxia-inducible factor-1 (HIF-1) is the major …

Hypoxia is associated with tumor radioresistance; therefore, a predictive marker for tumor
hypoxia and a rational target to overcome it have been sought to realize personalized …

Abstract Hypoxia-inducible factor-1 (HIF-1) has been reported to promote tumour
radioresistance; therefore, it is recognised as an excellent target during radiation therapy …

Tumors exhibit areas of decreased oxygenation due to malformed blood vessels. This low
oxygen concentration decreases the effectiveness of radiation therapy, and the resulting …