Results obtained from completed and on-going clinical studies indicate huge therapeutic
potential of stem cell-based therapy in the treatment of degenerative, autoimmune and …

During the past decades, extracellular vesicles (EVs) have emerged as an attractive drug
delivery system. Here, we assess their pre-clinical applications, in the form of a systematic …

Cell-replacement therapies have long been an attractive prospect for treating Parkinson
disease. However, the outcomes of fetal tissue-derived cell transplants in individuals with …

Parkinson disease (PD) treatment options have conventionally focused on dopamine
replacement and provision of symptomatic relief. Current treatments cause undesirable …

Human pluripotent stem cells (PSCs) are a promising source of cells for applications in
regenerative medicine. Directed differentiation of PSCs into specialized cells such as spinal …

Cell-based therapies are being developed for various neurodegenerative diseases that
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …

Human pluripotent stem cells (PSCs) are a leading candidate for cell-based therapies
because of their capacity for unlimited self renewal and pluripotent differentiation. These …

To model human neural-cell-fate specification and to provide cells for regenerative
therapies, we have developed a method to generate human neural progenitors and neurons …

Neonatal engraftment by oligodendrocyte progenitor cells (OPCs) permits the myelination of
the congenitally dysmyelinated brain. To establish a potential autologous source of these …

Human induced pluripotent stem cells (iPSCs) can provide a promising source of midbrain
dopaminergic (DA) neurons for cell replacement therapy for Parkinson's disease. However …