A sizeable literature exists on the use of frequentist power analysis in the null-hypothesis
significance testing (NHST) paradigm to facilitate the design of informative experiments. In …

Second generation p-values preserve the simplicity that has made p-values popular while
resolving critical flaws that promote misinterpretation of data, distraction by trivial effects, and …

Rolandic epilepsy (RE) is the most common human epilepsy, affecting children between 3
and 12 years of age, boys more often than girls (3: 2). Focal sharp waves in the …

Verifying that a statistically significant result is scientifically meaningful is not only good
scientific practice, it is a natural way to control the Type I error rate. Here we introduce a …

Bayesian inference is a formal method to combine evidence external to a study, represented
by a prior probability curve, with the evidence generated by the study, represented by a …

Researchers in fields ranging from biology and medicine to the social sciences, law, and
economics regularly encounter variables that are discrete or categorical in nature. While …

Applications of functional magnetic resonance imaging (fMRI) have provided novel insights
into the neuropathophysiology of major psychiatric, neurological, and substance abuse …

Adaptive design has become an important tool in modern pharmaceutical research and
development. Compared to a classic trial design with static features, an adaptive design …

J Clin Hypertens (Greenwich). 2012; 14: 316–321.© 2012 Wiley Periodicals, Inc. Despite
current guidelines, variability exists in the workup of hypertensive children due to physician …

Background Convalescent plasma has been one of the most common treatments for COVID-
19, but most clinical trial data to date have not supported its efficacy. Research Question Is …