Metal drugs and the anticancer immune response
B Englinger, C Pirker, P Heffeter, A Terenzi… - Chemical …, 2018 - ACS Publications
The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …
Dynamic matrisome: ECM remodeling factors licensing cancer progression and metastasis
The main cause of cancer-related mortality, metastasis, is a complex, multi-step process.
The extracellular matrix (ECM) component of solid tumors has been implicated in metastatic …
The extracellular matrix (ECM) component of solid tumors has been implicated in metastatic …
Biological targets and mechanisms of action of natural products from marine cyanobacteria
LA Salvador-Reyes, H Luesch - Natural product reports, 2015 - pubs.rsc.org
Covering: up to 2014 Marine cyanobacteria are an ancient group of organisms and prolific
producers of bioactive secondary metabolites. These compounds are presumably optimized …
producers of bioactive secondary metabolites. These compounds are presumably optimized …
[HTML][HTML] Copper activates HIF-1α/GPER/VEGF signalling in cancer cells
DC Rigiracciolo, A Scarpelli, R Lappano, A Pisano… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Copper promotes tumor angiogenesis, nevertheless the mechanisms involved remain to be
fully understood. We have recently demonstrated that the G-protein estrogen receptor …
fully understood. We have recently demonstrated that the G-protein estrogen receptor …
Targeting copper metabolism: a promising strategy for cancer treatment
R Kong, G Sun - Frontiers in Pharmacology, 2023 - frontiersin.org
Copper is an essential micronutrient that plays a critical role in many physiological
processes. However, excessive copper accumulation in cancer cells has been linked to …
processes. However, excessive copper accumulation in cancer cells has been linked to …
Re‐evaluation of the existing health‐based guidance values for copper and exposure assessment from all sources
EFSA Scientific Committee, SJ More, V Bampidis… - EFSA …, 2023 - Wiley Online Library
Copper is an essential micronutrient and also a regulated product used in organic and in
conventional farming pest management. Both deficiency and excessive exposure to copper …
conventional farming pest management. Both deficiency and excessive exposure to copper …
Advancing cancer therapy with copper/disulfiram nanomedicines and drug delivery systems
Disulfiram (DSF) is a thiocarbamate based drug that has been approved for treating
alcoholism for over 60 years. Preclinical studies have shown that DSF has anticancer …
alcoholism for over 60 years. Preclinical studies have shown that DSF has anticancer …
Serum copper concentration reflect inflammatory activation in the complex coronary artery disease–A pilot study
T Urbanowicz, A Hanć, A Olasińska-Wiśniewska… - Journal of Trace …, 2022 - Elsevier
Introduction Coronary artery disease possess inflammatory background related to enzymatic
processes with trace elements involvements as co-factors. The aim of the study was to …
processes with trace elements involvements as co-factors. The aim of the study was to …
Effects of Copper Chelation on BRAFV600E Positive Colon Carcinoma Cells
High affinity copper binding to mitogen-activated protein kinase kinase 1 (MAP2K1, also
known as MEK1) allosterically promotes the kinase activity of MEK1/2 on extracellular signal …
known as MEK1) allosterically promotes the kinase activity of MEK1/2 on extracellular signal …
Structure elucidation {spectroscopic, single crystal X-ray diffraction and computational DFT studies} of new tailored benzenesulfonamide derived Schiff base copper (II …
Z Afsan, T Roisnel, S Tabassum, F Arjmand - Bioorganic Chemistry, 2020 - Elsevier
New tailored copper (II)–based intercalating complexes [Cu (L 1) 2](1) and [Cu (L 2) 2](2)
were synthesized from Schiff base scaffold HL 1 and HL 2 (E)-4-(2-((2-hydroxy-3 …
were synthesized from Schiff base scaffold HL 1 and HL 2 (E)-4-(2-((2-hydroxy-3 …