The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …

The main cause of cancer-related mortality, metastasis, is a complex, multi-step process.
The extracellular matrix (ECM) component of solid tumors has been implicated in metastatic …

Covering: up to 2014 Marine cyanobacteria are an ancient group of organisms and prolific
producers of bioactive secondary metabolites. These compounds are presumably optimized …

Copper promotes tumor angiogenesis, nevertheless the mechanisms involved remain to be
fully understood. We have recently demonstrated that the G-protein estrogen receptor …

Copper is an essential micronutrient that plays a critical role in many physiological
processes. However, excessive copper accumulation in cancer cells has been linked to …

Copper is an essential micronutrient and also a regulated product used in organic and in
conventional farming pest management. Both deficiency and excessive exposure to copper …

Disulfiram (DSF) is a thiocarbamate based drug that has been approved for treating
alcoholism for over 60 years. Preclinical studies have shown that DSF has anticancer …

Introduction Coronary artery disease possess inflammatory background related to enzymatic
processes with trace elements involvements as co-factors. The aim of the study was to …

High affinity copper binding to mitogen-activated protein kinase kinase 1 (MAP2K1, also
known as MEK1) allosterically promotes the kinase activity of MEK1/2 on extracellular signal …

New tailored copper (II)–based intercalating complexes [Cu (L 1) 2](1) and [Cu (L 2) 2](2)
were synthesized from Schiff base scaffold HL 1 and HL 2 (E)-4-(2-((2-hydroxy-3 …