Glutamate-mediated excitotoxicity is an important mechanism leading to post ischemic
stroke damage. After acute stroke, the sudden reduction in cerebral blood flow is most …

Gallic acid (GA) is a phenolic molecule found naturally in a wide range of fruits as well as in
medicinal plants. It has many health benefits due to its antioxidant properties. This study …

Stroke and circulatory arrest cause interferences in blood flow to the brain that result in
considerable tissue damage. The primary method to reduce or prevent neurologic damage …

Cerebral ischemia-reperfusion injury can lead to a series of serious brain diseases and
cause death or different degrees of disability. Polysaccharide is a kind of biological …

Sublethal hypoxic or ischemic events can improve the tolerance of tissues, organs, and even
organisms from subsequent lethal injury caused by hypoxia or ischemia. This phenomenon …

A variety of neuroprotectants have shown promise in treating ischemic stroke, yet their
delivery to the brain remains a challenge. The endothelial cells lining the blood-brain barrier …

Poly (ADP‐ribose) polymerase‐1 (PARP‐1) is an abundant nuclear protein best known to
facilitate DNA base excision repair. Recent work has expanded the physiologic functions of …

Mitochondrial oxidative stress is associated with many neurodegenerative diseases, such as
traumatic brain injury (TBI). Targeted delivery of antioxidants to mitochondria has failed to …

A number of recent discoveries indicate that abnormal Ca 2+ signaling, oxidative stress, and
mitochondrial dysfunction are involved in the neuronal damage in Alzheimer's disease …

Rapamycin has been demonstrated to exhibit neuroprotective functions via the activation of
autophagy in a cerebral ischemia model. However, the involvement of mitophagy in this …