TFOS DEWS II pain and sensation report

C Belmonte, JJ Nichols, SM Cox, JA Brock, CG Begley… - The ocular …, 2017 - Elsevier
Pain associated with mechanical, chemical, and thermal heat stimulation of the ocular
surface is mediated by trigeminal ganglion neurons, while cold thermoreceptors detect …

Neurotrophic keratopathy

HS Dua, DG Said, EM Messmer, M Rolando… - Progress in retinal and …, 2018 - Elsevier
Neurotrophic Keratopathy (NK) refers to a condition where corneal epitheliopathy leading to
frank epithelial defect with or without stromal ulceration (melting) is associated with reduced …

TFOS DEWS II sex, gender, and hormones report

DA Sullivan, EM Rocha, P Aragona, JA Clayton, J Ding… - The ocular …, 2017 - Elsevier
One of the most compelling features of dry eye disease (DED) is that it occurs more
frequently in women than men. In fact, the female sex is a significant risk factor for the …

Corneal nerves in health and disease

MA Al-Aqaba, VK Dhillon, I Mohammed… - Progress in retinal and …, 2019 - Elsevier
The cornea is the most sensitive structure in the human body. Corneal nerves adapt to
maintain transparency and contribute to corneal health by mediating tear secretion and …

In vivo confocal microscopy of corneal nerves in health and disease

A Cruzat, Y Qazi, P Hamrah - The ocular surface, 2017 - Elsevier
In vivo confocal microscopy (IVCM) is becoming an indispensable tool for studying corneal
physiology and disease. Enabling the dissection of corneal architecture at a cellular level …

Corneal nerves in health and disease

BS Shaheen, M Bakir, S Jain - Survey of ophthalmology, 2014 - Elsevier
Corneal nerves are responsible for the sensations of touch, pain, and temperature and play
an important role in the blink reflex, wound healing, and tear production and secretion …

Role of corneal nerves in ocular surface homeostasis and disease

M Labetoulle, C Baudouin, M Calonge… - Acta …, 2019 - Wiley Online Library
Corneal nerves are key components of the physiological system that controls ocular surface
homeostasis. The cornea is primarily innervated by the ophthalmic branch of the trigeminal …

TFOS Lifestyle: Impact of lifestyle challenges on the ocular surface

A Galor, AC Britten-Jones, Y Feng, G Ferrari… - The ocular …, 2023 - Elsevier
Many factors in the domains of mental, physical, and social health have been associated
with various ocular surface diseases, with most of the focus centered on aspects of dry eye …

Neuropathic pain and dry eye

A Galor, HR Moein, C Lee, A Rodriguez, ER Felix… - The ocular …, 2018 - Elsevier
Dry eye is a common, multifactorial disease currently diagnosed by a combination of
symptoms and signs. Its epidemiology and clinical presentation have many similarities with …

TFOS Lifestyle: Impact of elective medications and procedures on the ocular surface

JAP Gomes, DT Azar, C Baudouin, E Bitton, W Chen… - The Ocular Surface, 2023 - Elsevier
The word “elective” refers to medications and procedures undertaken by choice or with a
lower grade of prioritization. Patients usually use elective medications or undergo elective …