The human breast cancer resistance protein (BCRP, gene symbol ABCG2) is an ATP-
binding cassette (ABC) efflux transporter. It was so named because it was initially cloned …

The drug efflux transporters ABCB1 and ABCG2 at the blood-brain barrier limit the delivery
of drugs into the brain. Strategies to overcome ABCB1/ABCG2 have been largely …

Resistance to conventional and target specific antitumor drugs still remains one of the major
cause of treatment failure and patience death. This condition often involves ATP-binding …

Since cloning of the ATP-binding cassette (ABC) family member breast cancer resistance
protein (BCRP/ABCG2) and its characterization as a multidrug resistance efflux transporter …

In this review we give an overview of the physiological functions of a group of ATP binding
cassette (ABC) transporter proteins, which were discovered, and still referred to, as …

Breast cancer resistance protein (BCRP)/ATP-binding cassette subfamily G member 2
(ABCG2) is an ATP-binding cassette (ABC) transporter identified as a molecular cause of …

Human ABCG2 is a member of the ATP-binding cassette (ABC) transporter superfamily and
is known to contribute to multidrug resistance (MDR) in cancer chemotherapy. Among ABC …

The protection of the body's stem cells from damage or death due to toxins is a critical
function of an organism, as the stem cells need to remain intact for the entire life of the …

Introduction Breast cancer is a heterogeneous disease encompassing a number of
phenotypically diverse tumours. Expression levels of the oestrogen, progesterone and …

ABCG2, or breast cancer resistance protein (BCRP), is an ABC transporter that has been the
subject of intense study since its discovery a decade ago. With high normal tissue …