Pharmacokinetic models range from being entirely exploratory and empirical, to semi‐
mechanistic and ultimately complex physiologically based pharmacokinetic (PBPK) models …

This review summarizes the most recent developments in and applications of physiologically
based pharmacokinetic (PBPK) modeling methodology originating from both the …

The concept of physiologically based pharmacokinetic (PBPK) modeling was introduced
years ago, but it has not been practiced significantly. However, interest in and …

Motivation Gene–environment interaction (GEI) studies are a general framework that can be
used to identify genetic variants that modify the effects of environmental, physiological …

This study describes the development and intercomparison of generic physiologically-based
toxicokinetic (PBTK) models for humans comprised of internally consistent one-compartment …

In drug discovery and development, classical compartment models and physiologically
based pharmacokinetic (PBPK) models are successfully used to analyze and predict the …

Currently it is difficult to prospectively estimate human toxicokinetics (particularly for novel
chemicals) in a high-throughput manner. The R software package httk has been developed …

Whole‐body physiologically‐based pharmacokinetic (PBPK) models have many
applications in drug research and development. It is often necessary to inform these models …

Minimal physiologically based pharmacokinetic (mPBPK) models, consisting of system-
specific (eg, tissue volume and blood flow) and drug-related (eg, tissue-to-plasma partition …

An algorithm for automatic order reduction of models defined by large systems of differential
equations is presented. The algorithm was developed with systems biology models in mind …