For decades, immunologists have studied the role of circulating immune cells in host
protection, with a more recent appreciation of immune cells resident within the tissue …

Monocyte chemoattractant protein-1 (MCP-1/CCL2) is renowned for its ability to drive the
chemotaxis of myeloid and lymphoid cells. It orchestrates the migration of these cell types …

The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that
signal through cell surface G protein‐coupled heptahelical chemokine receptors. They are …

Radiotherapy (RT) is a highly effective anticancer treatment that is delivered to more than
half of all patients with cancer. In addition to the well-documented direct cytotoxic effects, RT …

Type 2 immunity mediates protective responses to helminths and pathological responses to
allergens, but it also has broad roles in the maintenance of tissue integrity, including wound …

The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …

The inflammatory chemokines CXCL9, CXCL10, and CXCL11 are predominantly induced
by interferon (IFN)-γ and share an exclusive chemokine receptor named CXC chemokine …

The chemokine CXCL1/MGSA plays a pivotal role in the host immune response by recruiting
and activating neutrophils for microbial killing at the tissue site. CXCL1 exists reversibly as …

Chemokines are a family of small, highly conserved cytokines that mediate various
biological processes, including chemotaxis, hematopoiesis, and angiogenesis, and that …

Leukocyte recruitment from the vasculature into tissues is a crucial component of the
immune system but is also key to inflammatory disease. Chemokines are central to this …