Membrane protrusions at the leading edge of cells, known as lamellipodia, drive cell
migration in many normal and pathological situations. Lamellipodial protrusion is powered …

The Arp2/3 complex is an evolutionary conserved molecular machine that generates
branched actin networks. When activated, the Arp2/3 complex contributes the actin …

Background—Epigenetic alterations may contribute to the development of atherosclerosis.
In particular, DNA methylation, a reversible and highly regulated DNA modification, could …

MicroRNAs (miRNAs) regulate cardiovascular biology and disease, but the role of flow-
sensitive microRNAs in atherosclerosis is still unclear. Here we identify miRNA-712 (miR …

Background Uterine corpus endometrial carcinoma (UCEC) is a gynecological malignant
tumor with low survival rate and poor prognosis. The traditional clinicopathological staging is …

Smooth muscle cell (SMC) proliferation and fibrosis contribute to the development of
advanced atherosclerotic lesions. Oxidative stress caused by increased production or …

Background and aims Neointima hyperplasia is the pathological basis of atherosclerosis
and restenosis, which have been associated with diabetes mellitus (DM). Fibroblast growth …

Abstract Doublecortin‐like kinase 1 (DCLK1) is a putative cancer stem cell marker, a
promising diagnostic and prognostic maker for malignant tumors and a proposed driver …

Increased aerobic glycolysis is a recognized feature of multiple cellular phenotypes and
offers a potential point for drug interference, as pursued by anti-tumor agents targeting the …

Lenalidomide is an immunomodulatory agent clinically active in chronic lymphocytic
leukemia patients. The specific mechanism of action is still undefined, but includes …