Epigenetic regulation of mitochondrial DNA (mtDNA) is an emerging and fast-developing
field of research. Compared to regulation of nucler DNA, mechanisms of mtDNA epigenetic …

Breast cancer is one of the most common malignancy among women worldwide. Metastasis
is mainly responsible for treatment failure and is the cause of most breast cancer deaths …

Breast cancer (BC) is mostly observed in women and is responsible for huge mortality in
women subjects globally. Due to the continued development of drug resistance and other …

Breast cancer is the second leading cause of death for women worldwide. While
monotherapy (single agent) treatments have been used for many years, they are not always …

Metformin is a widely prescribed hypoglycemic drug. Many studies have shown its anti-
cancer properties. In the present study, we aimed to explore the effect of metformin on breast …

Due to their crucial role in cell metabolism and homeostasis, alterations in mitochondrial
biology and function have been related to the progression of diverse diseases including …

Background Type 2 diabetes (T2D) has been associated with increased breast cancer risk,
but commonly prescribed antidiabetic medications such as metformin may reduce risk. Few …

Abstract Traditional Chinese medicines (TCMs) produce chemically diverse functional
compounds that are importantly chemical resource for facilitating new drug discovery and …

Biguanides are compounds in which two guanidine moieties are fused to form a highly
conjugated system. Biguanides are highly basic and hence they are available as salts …

Simple Summary This literature analysis is focused on the pleiotropic action associated with
metformin treatment. Precisely, metformin treatment exerts many health effects, mainly by …