Around the world, over 6 million people are affected by primary immunodeficiencies, among
which 70 to 90% remain undiagnosed (1). More than 430 different primary …

Background Severe Combined Immune Deficiency (SCID) is an inherited defect in
lymphocyte development and function that results in life-threatening opportunistic infections …

Background There is paucity of literature on XLA from developing countries. Herein we
report the clinical and molecular profile and outcome in a multicenter cohort of patients with …

Objective To analyze the implementation of the Principles of Care (PoC) in primary
immunodeficiencies (PID) in Southeast Asia (SEA) countries-six years after its call of action …

Background Inborn errors of immunity (IEI) predispose patients to various infectious and non-
infectious complications. Thanks to the development and expanding use of flow cytometry …

Background Hematopoietic stem cell transplantation (HSCT) is the curative option for many
primary immune deficiency disorders (PID). In the last 5 years, increased awareness …

Background Chronic granulomatous disease (CGD) is an inborn error of immunity (IEI),
characterised by recurrent bacterial and fungal infections. It is inherited either in an X-linked …

To address inborn errors of immunity (IEI) which were underdiagnosed in resource-limited
regions, our centre developed and offered free genetic testing for the most common IEI by …

Background Chronic granulomatous disease (CGD) is an inborn error of immunity (IEI)
disorder that results from defects in the respiratory burst activity in phagocytes, leading to the …

The Research Topic for this series of 6 articles is “Emerging Talents in Primary
Immunodeficiencies 2022”. The goal of this Research Topic is to facilitate the young doctors …