While modernization has dramatically increased lifespan, it has also witnessed the nature of
stress has changed dramatically. Chronic stress result failures of homeostasis and thus lead …

Aging is the main risk factor for neurodegenerative diseases. In aging, microglia undergoes
phenotypic changes compatible with their activation. Glial activation can lead to …

Alzheimer's disease (AD) is a progressive neurodegenerative disease and the most
common cause of dementia. Deposition of amyloid‐β (Aβ) remains a hallmark feature of the …

Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by the
accumulation of amyloid plaques and neurofibrillary tangles in the brain. The AD …

Alzheimer's disease (AD) is a complex disorder and the most common form of
neurodegenerative dementia. Several genetic, environmental, and physiological factors …

From Alois Alzheimer's description of Auguste D.'s brain in 1907 to George Glenner's
biochemical dissection of β-amyloid in 1984, the" amyloid hypothesis" of Alzheimer's …

Alzheimer's disease is one of the most common age-related neurodegenerative disorders.
The main theory of Alzheimer's disease progress is the amyloid-β cascade hypothesis …

Ageing is accompanied by 2–4-fold increases in plasma/serum levels of inflammatory
mediators such as cytokines and acute phase proteins. A wide range of factors seems to …

Considerable evidence gained over the past decade has supported the conclusion that
neuroinflammation is associated with Alzheimer's disease (AD) pathology. Inflammatory …

The brain is not only immunologically active of its own accord, but also has complex
peripheral immune interactions. Given the central role of cytokines in …