The functions of the proto-oncoprotein c-Myc and the tumor suppressor p53 in controlling
cell survival and proliferation are inextricably linked as “Yin and Yang” partners in normal …

Long non-coding RNAs (lncRNAs) play important roles in carcinogenesis and drug efficacy.
Platinum-based chemotherapy is first-line treatment for lung cancer chemotherapy. In this …

Genetic alterations in the INK4a/ARF (or CDKN2A) locus have been reported in many
cancer types, including melanoma; head and neck squamous cell carcinomas; lung, breast …

Osteosarcoma is the most common form of bone cancer. Pivotal insight into the genes
involved in human osteosarcoma has been provided by the study of rare familial cancer …

Platinum-based chemotherapy is the standard first-line treatment for most lung cancer
patients. However, the toxicity induced by platinum-based chemotherapy greatly impedes its …

Metastatic cutaneous melanoma is highly resistant to cytotoxic drugs, and this contributes to
poor prognosis. In vivo studies on the chemosensitivity of metastatic melanoma are rare and …

Genetic polymorphisms are defined as the presence of two or more different alleles in the
same locus, with a frequency higher than 1% in the population. Since the discovery of long …

Oxidative stress as a result of either exogenous stimuli or cellular metabolism affects several
cellular processes such as proliferation, apoptosis, cell death and senescence …

p53 在DNA 损伤诱导细胞凋亡中发挥关键作用, 但p53 基因在大多数肿瘤细胞中易发生突变,
突变率可超过50%. 目前研究发现, p73, p63, Caspase2, NF-KB 等蛋白介导的信号通路能够在 …

Specific binding of either soluble Fas ligand extracellular domain (sFasL) or agonistic anti-
Fas receptor extracellular-domain monoclonal-antibodies (FasR-mAb) can trigger apoptotic …