Immunoglobulin class-switch DNA recombination: induction, targeting and beyond
Class-switch DNA recombination (CSR) of the immunoglobulin heavy chain (IGH) locus is
central to the maturation of the antibody response and crucially requires the cytidine …
central to the maturation of the antibody response and crucially requires the cytidine …
Gonadal steroids and humoral immunity
S Sakiani, NJ Olsen, WJ Kovacs - Nature Reviews Endocrinology, 2013 - nature.com
Humoral immune responses are sexually dimorphic. Female individuals generally exhibit
more-robust antibody responses to vaccines and, in the clinical setting as well as in …
more-robust antibody responses to vaccines and, in the clinical setting as well as in …
B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids
HN Sanchez, JB Moroney, H Gan, T Shen, JL Im… - Nature …, 2020 - nature.com
Short-chain fatty acids (SCFAs) butyrate and propionate are metabolites from dietary fiber's
fermentation by gut microbiota that can affect differentiation or functions of T cells …
fermentation by gut microbiota that can affect differentiation or functions of T cells …
Histone deacetylase inhibitors upregulate B cell microRNAs that silence AID and Blimp-1 expression for epigenetic modulation of antibody and autoantibody …
Class-switch DNA recombination (CSR) and somatic hypermutation (SHM), which require
activation-induced cytidine deaminase (AID), and plasma cell differentiation, which requires …
activation-induced cytidine deaminase (AID), and plasma cell differentiation, which requires …
Epigenetics of peripheral B-cell differentiation and the antibody response
Epigenetic modifications, such as histone post-translational modifications, DNA methylation,
and alteration of gene expression by non-coding RNAs, including microRNAs (miRNAs) and …
and alteration of gene expression by non-coding RNAs, including microRNAs (miRNAs) and …
Gender-diverse inclusion in immunological research: benefits to science and health
The differences between male and female immune systems are an under-researched field,
ripe for discovery. This is evidenced by the stark sex biases seen in autoimmunity and …
ripe for discovery. This is evidenced by the stark sex biases seen in autoimmunity and …
Transcriptional regulation of B cell class-switch recombination: the role in development of noninfectious complications
S Vlachiotis, H Abolhassani - Expert Review of Clinical …, 2022 - Taylor & Francis
Introduction The process of immunoglobulin class switch recombination (CSR) occurs in
secondary lymphoid organs. This highly regulated process is essential for the development …
secondary lymphoid organs. This highly regulated process is essential for the development …
B cell TLR1/2, TLR4, TLR7 and TLR9 interact in induction of class switch DNA recombination: modulation by BCR and CD40, and relevance to T-independent …
Ig class switch DNA recombination (CSR) in B cells is crucial to the maturation of antibody
responses. It requires IgH germline IH-CH transcription and expression of AID, both of which …
responses. It requires IgH germline IH-CH transcription and expression of AID, both of which …