In heart failure, alterations of Na+ and Ca2+ handling, energetic deficit, and oxidative stress
in cardiac myocytes are important pathophysiological hallmarks. Mitochondria are central to …

Byproducts of normal mitochondrial metabolism and homeostasis include the buildup of
potentially damaging levels of reactive oxygen species (ROS), Ca2+, etc., which must be …

Exercise training has been widely recognized as a healthy lifestyle as well as an effective
non-drug therapeutic strategy for cardiovascular diseases (CVD). Functional and …

Calcium (Ca2+) uptake into the mitochondrial matrix is critically important to cellular function.
As a regulator of matrix Ca2+ levels, this flux influences energy production and can initiate …

The intact heart undergoes complex and multiscale remodelling processes in response to
altered mechanical cues. Remodelling of the myocardium is regulated by a combination of …

Stimulation of mitochondrial oxidative metabolism by Ca2+ is now generally recognised as
important for the control of cellular ATP homeostasis. Here, we review the mechanisms …

The heart is a fantastic machine; during a normal lifetime it beats about 2.5 billion times and
pumps 200.000 tons of blood through an enormous system of vessels extending 160.000 …

Mitochondrial Ca2+ transport was initially considered important only in buffering of cytosolic
Ca2+ by acting as a “sink” under conditions of Ca2+ overload. The main regulator of ATP …

Reactive oxygen species (ROS) and/or Ca 2+ overload can trigger depolarization of
mitochondrial inner membrane potential (ΔΨ m) and cell injury. Little is known about how …

The study of cellular signalling over the past 20 years and the advent of high-throughput
technologies are enabling the reconstruction of large-scale signalling networks. After careful …