Protein language: post-translational modifications talking to each other

L Dai Vu, K Gevaert, I De Smet - Trends in plant science, 2018 - cell.com
Post-translational modifications (PTMs) are at the heart of many cellular signaling events.
Apart from a single regulatory PTM, there are also PTMs that function in orchestrated …

[HTML][HTML] Protein post-translational modifications: In silico prediction tools and molecular modeling

M Audagnotto, M Dal Peraro - Computational and structural biotechnology …, 2017 - Elsevier
Post-translational modifications (PTMs) occur in almost all proteins and play an important
role in numerous biological processes by significantly affecting proteins' structure and …

qPTM: an updated database for PTM dynamics in human, mouse, rat and yeast

K Yu, Y Wang, Y Zheng, Z Liu, Q Zhang… - Nucleic Acids …, 2023 - academic.oup.com
Post-translational modifications (PTMs) are critical molecular mechanisms that regulate
protein functions temporally and spatially in various organisms. Since most PTMs are …

Complex regulatory mechanisms mediated by the interplay of multiple post-translational modifications

V Csizmok, JD Forman-Kay - Current opinion in structural biology, 2018 - Elsevier
Highlights•Multiple PTMs can coordinately determine a functional outcome.•Functional
consequences depend on the effects, number, positioning and type of PTMs.•PTM interplay …

Crosstalk of intracellular post-translational modifications in cancer

Z Wu, R Huang, L Yuan - Archives of biochemistry and biophysics, 2019 - Elsevier
Post-translational modifications (PTMs) have been reported to play pivotal roles in
numerous cellular biochemical and physiological processes. Multiple PTMs can influence …

[HTML][HTML] Dissecting structure-encoded determinants of allosteric cross-talk between post-translational modification sites in the Hsp90 chaperones

G Stetz, A Tse, GM Verkhivker - Scientific reports, 2018 - nature.com
Post-translational modifications (PTMs) represent an important regulatory instrument that
modulates structure, dynamics and function of proteins. The large number of PTM sites in the …

Recent advances in phosphoproteomics and application to neurological diseases

JV Arrington, CC Hsu, SG Elder, WA Tao - Analyst, 2017 - pubs.rsc.org
Phosphorylation has an incredible impact on the biological behavior of proteins, altering
everything from intrinsic activity to cellular localization and complex formation. It is no …

Shot-gun proteomics: why thousands of unidentified signals matter

M den Ridder, P Daran-Lapujade… - FEMS yeast …, 2020 - academic.oup.com
Mass spectrometry-based proteomics has become a constitutional part of the multi-omics
toolbox in yeast research, advancing fundamental knowledge of molecular processes and …

Peptide-templated gold nanoparticle nanosensor for simultaneous detection of multiple posttranslational modification enzymes

D Zhang, Y Meng, C Zhang - Chemical communications, 2019 - pubs.rsc.org
We developed a peptide-templated gold nanoparticle (AuNP) nanosensor for simultaneous
detection of multiple posttranslational modification (PTM) enzymes with a detection limit of …

PPICT: an integrated deep neural network for predicting inter-protein PTM cross-talk

F Zhu, L Deng, Y Dai, G Zhang, F Meng… - Briefings in …, 2023 - academic.oup.com
Post-translational modifications (PTMs) fine-tune various signaling pathways not only by the
modification of a single residue, but also by the interplay of different modifications on residue …