Protein language: post-translational modifications talking to each other
Post-translational modifications (PTMs) are at the heart of many cellular signaling events.
Apart from a single regulatory PTM, there are also PTMs that function in orchestrated …
Apart from a single regulatory PTM, there are also PTMs that function in orchestrated …
[HTML][HTML] Protein post-translational modifications: In silico prediction tools and molecular modeling
M Audagnotto, M Dal Peraro - Computational and structural biotechnology …, 2017 - Elsevier
Post-translational modifications (PTMs) occur in almost all proteins and play an important
role in numerous biological processes by significantly affecting proteins' structure and …
role in numerous biological processes by significantly affecting proteins' structure and …
qPTM: an updated database for PTM dynamics in human, mouse, rat and yeast
K Yu, Y Wang, Y Zheng, Z Liu, Q Zhang… - Nucleic Acids …, 2023 - academic.oup.com
Post-translational modifications (PTMs) are critical molecular mechanisms that regulate
protein functions temporally and spatially in various organisms. Since most PTMs are …
protein functions temporally and spatially in various organisms. Since most PTMs are …
Complex regulatory mechanisms mediated by the interplay of multiple post-translational modifications
V Csizmok, JD Forman-Kay - Current opinion in structural biology, 2018 - Elsevier
Highlights•Multiple PTMs can coordinately determine a functional outcome.•Functional
consequences depend on the effects, number, positioning and type of PTMs.•PTM interplay …
consequences depend on the effects, number, positioning and type of PTMs.•PTM interplay …
Crosstalk of intracellular post-translational modifications in cancer
Z Wu, R Huang, L Yuan - Archives of biochemistry and biophysics, 2019 - Elsevier
Post-translational modifications (PTMs) have been reported to play pivotal roles in
numerous cellular biochemical and physiological processes. Multiple PTMs can influence …
numerous cellular biochemical and physiological processes. Multiple PTMs can influence …
[HTML][HTML] Dissecting structure-encoded determinants of allosteric cross-talk between post-translational modification sites in the Hsp90 chaperones
G Stetz, A Tse, GM Verkhivker - Scientific reports, 2018 - nature.com
Post-translational modifications (PTMs) represent an important regulatory instrument that
modulates structure, dynamics and function of proteins. The large number of PTM sites in the …
modulates structure, dynamics and function of proteins. The large number of PTM sites in the …
Recent advances in phosphoproteomics and application to neurological diseases
Phosphorylation has an incredible impact on the biological behavior of proteins, altering
everything from intrinsic activity to cellular localization and complex formation. It is no …
everything from intrinsic activity to cellular localization and complex formation. It is no …
Shot-gun proteomics: why thousands of unidentified signals matter
M den Ridder, P Daran-Lapujade… - FEMS yeast …, 2020 - academic.oup.com
Mass spectrometry-based proteomics has become a constitutional part of the multi-omics
toolbox in yeast research, advancing fundamental knowledge of molecular processes and …
toolbox in yeast research, advancing fundamental knowledge of molecular processes and …
Peptide-templated gold nanoparticle nanosensor for simultaneous detection of multiple posttranslational modification enzymes
D Zhang, Y Meng, C Zhang - Chemical communications, 2019 - pubs.rsc.org
We developed a peptide-templated gold nanoparticle (AuNP) nanosensor for simultaneous
detection of multiple posttranslational modification (PTM) enzymes with a detection limit of …
detection of multiple posttranslational modification (PTM) enzymes with a detection limit of …
PPICT: an integrated deep neural network for predicting inter-protein PTM cross-talk
F Zhu, L Deng, Y Dai, G Zhang, F Meng… - Briefings in …, 2023 - academic.oup.com
Post-translational modifications (PTMs) fine-tune various signaling pathways not only by the
modification of a single residue, but also by the interplay of different modifications on residue …
modification of a single residue, but also by the interplay of different modifications on residue …