NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

P Paoletti, C Bellone, Q Zhou - Nature Reviews Neuroscience, 2013 - nature.com
NMDA receptors (NMDARs) are glutamate-gated ion channels and are crucial for neuronal
communication. NMDARs form tetrameric complexes that consist of several homologous …

NMDA receptor functions in health and disease: Old actor, new dimensions

JP Dupuis, O Nicole, L Groc - Neuron, 2023 - cell.com
N-Methyl-D-aspartate ionotropic glutamate receptors (NMDARs) play key roles in
synaptogenesis, synaptic maturation, long-term plasticity, neuronal network activity, and …

Multiple sclerosis and cognition: synaptic failure and network dysfunction

M Di Filippo, E Portaccio, A Mancini… - Nature Reviews …, 2018 - nature.com
Cognitive impairment is increasingly recognized to be a core feature of multiple sclerosis
(MS), with important implications for the everyday life of individuals with MS and for disease …

Hippocampal insulin resistance impairs spatial learning and synaptic plasticity

CA Grillo, GG Piroli, RC Lawrence, SA Wrighten… - Diabetes, 2015 - Am Diabetes Assoc
Insulin receptors (IRs) are expressed in discrete neuronal populations in the central nervous
system, including the hippocampus. To elucidate the functional role of hippocampal IRs …

Na+/K+-pump and neurotransmitter membrane receptors

AS Pivovarov, F Calahorro, RJ Walker - Invertebrate Neuroscience, 2019 - Springer
Abstract Na+/K+-pump is an electrogenic transmembrane ATPase located in the outer
plasma membrane of cells. The Na+/K+-ATPase pumps 3 sodium ions out of cells while …

GluN2A and GluN2B subunit-containing NMDA receptors in hippocampal plasticity

OA Shipton, O Paulsen - Philosophical Transactions of …, 2014 - royalsocietypublishing.org
N-Methyl-d-aspartate receptor (NMDAR)-dependent synaptic plasticity is a strong candidate
to mediate learning and memory processes that require the hippocampus. This plasticity is …

Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning

JL Brigman, T Wright, G Talani… - Journal of …, 2010 - Soc Neuroscience
NMDA receptors (NMDARs) are key mediators of certain forms of synaptic plasticity and
learning. NMDAR complexes are heteromers composed of an obligatory GluN1 subunit and …

Effects of central and peripheral inflammation on hippocampal synaptic plasticity

M Di Filippo, D Chiasserini, F Gardoni, B Viviani… - Neurobiology of …, 2013 - Elsevier
The central nervous system (CNS) and the immune system are known to be engaged in an
intense bidirectional crosstalk. In particular, the immune system has the potential to …

Astrocytes and human cognition: modeling information integration and modulation of neuronal activity

A Pereira Jr, FA Furlan - Progress in neurobiology, 2010 - Elsevier
Recent research focusing on the participation of astrocytes in glutamatergic tripartite
synapses has revealed mechanisms that support cognitive functions common to human and …

Differential nanoscale topography and functional role of GluN2-NMDA receptor subtypes at glutamatergic synapses

B Kellermayer, JS Ferreira, J Dupuis, F Levet… - Neuron, 2018 - cell.com
NMDA receptors (NMDARs) play key roles in the use-dependent adaptation of glutamatergic
synapses underpinning memory formation. In the forebrain, these plastic processes involve …