Colorectal cancer is one of the most common cancers worldwide with high mortality. Distant
metastasis and relapse are major causes of patient death. Cancer stem cells (CSCs) play a …

Accumulating evidence has demonstrated that human cancers arise from various tissues of
origin that initiate from cancer stem cells (CSCs) or cancer-initiating cells. The extrinsic and …

Pancreatic cancer, mostly pancreatic ductal adenocarcinomas (PDAC), is one of the most
lethal cancers, with a dismal median survival around 8 months. PDAC is notoriously …

Receptor tyrosine kinase (RTK) anaplastic lymphoma kinase (ALK) serves a crucial role in
brain development. ALK is located on the short arm of chromosome 2 (2p23) and exchange …

High aldehyde dehydrogenase (ALDH) activity is a metabolic feature of adult stem cells and
various cancer stem cells (CSCs). The ALDEFLUOR system is currently the most commonly …

Gastric and colorectal cancers have a high incidence and mortality worldwide. The presence
of cancer stem cells (CSCs) within the tumor mass has been indicated as the main reason …

Leptin, an adipocyte-derived hormone and its receptor (ObR) expressed in the
hypothalamus are well known as an essential regulator of appetite and energy expenditure …

Background Accumulative evidence suggests that the biological behavior of cancer stem-
like cells (CSCs) is regulated by their surrounding niche, in which cytokines function as one …

Gastric cancer (GC) is a leading cause of cancer-related death with poor prognosis. Growing
evidence has shown that long noncoding ribonucleic acid (lncRNA) FEZ family zinc finger 1 …

The majority of colorectal cancers (CRCs) are thought to arise from precancerous
adenomas. Upon exposure to diverse microenvironmental factors, precancerous stem cells …