Melatonin as a hormone: new physiological and clinical insights

J Cipolla-Neto, FG Amaral - Endocrine reviews, 2018 - academic.oup.com
Melatonin is a ubiquitous molecule present in almost every live being from bacteria to
humans. In vertebrates, besides being produced in peripheral tissues and acting as an …

Melatonin, energy metabolism, and obesity: a review

J Cipolla‐Neto, FG Amaral, SC Afeche… - Journal of pineal …, 2014 - Wiley Online Library
Melatonin is an old and ubiquitous molecule in nature showing multiple mechanisms of
action and functions in practically every living organism. In mammals, pineal melatonin …

Insulin/IGF-1 drives PERIOD synthesis to entrain circadian rhythms with feeding time

P Crosby, R Hamnett, M Putker, NP Hoyle, M Reed… - Cell, 2019 - cell.com
In mammals, endogenous circadian clocks sense and respond to daily feeding and lighting
cues, adjusting internal∼ 24 h rhythms to resonate with, and anticipate, external cycles of …

Mechanisms of melatonin in alleviating Alzheimer's disease

M Shukla, P Govitrapong, P Boontem… - Current …, 2017 - ingentaconnect.com
Alzheimer's disease (AD) is a chronic, progressive and prevalent neurodegenerative
disease characterized by the loss of higher cognitive functions and an associated loss of …

Melatonin: A potential nighttime guardian against Alzheimer's

Z Zhang, P Xue, BB Bendlin, H Zetterberg… - Molecular …, 2024 - nature.com
In the context of the escalating global health challenge posed by Alzheimer's disease (AD),
this comprehensive review considers the potential of melatonin in both preventive and …

Leptin's role in lipodystrophic and nonlipodystrophic insulin-resistant and diabetic individuals

HS Moon, M Dalamaga, SY Kim, SA Polyzos… - Endocrine …, 2013 - academic.oup.com
Leptin is an adipocyte-secreted hormone that has been proposed to regulate energy
homeostasis as well as metabolic, reproductive, neuroendocrine, and immune functions. In …

Alzheimer's disease: pathological mechanisms and the beneficial role of melatonin

SA Rosales‐Corral, D Acuña‐Castroviejo… - Journal of pineal …, 2012 - Wiley Online Library
Alzheimer's disease (AD) is a highly complex neurodegenerative disorder of the aged that
has multiple factors which contribute to its etiology in terms of initiation and progression. This …

Modulation of apoptosis by melatonin for improving cancer treatment efficiency: An updated review

K Mortezaee, M Najafi, B Farhood, A Ahmadi, Y Potes… - Life sciences, 2019 - Elsevier
Radio-and chemotherapy are the most common cancer treatment modalities. They cause
acute and late side effects on normal tissues, which is a burden for delivery of a high dose of …

Melatonin and pancreatic islets: interrelationships between melatonin, insulin and glucagon

E Peschke, I Bähr, E Mühlbauer - International journal of molecular …, 2013 - mdpi.com
The pineal hormone melatonin exerts its influence in the periphery through activation of two
specific trans-membrane receptors: MT1 and MT2. Both isoforms are expressed in the islet …

Melatonin as a regulator of apoptosis in leukaemia: molecular mechanism and therapeutic perspectives

A Mafi, H Rismanchi, Y Gholinezhad… - Frontiers in …, 2023 - frontiersin.org
Leukaemia is a dangerous malignancy that causes thousands of deaths every year
throughout the world. The rate of morbidity and mortality is significant despite many …