Innate immune and inflammatory responses to SARS-CoV-2: Implications for COVID-19
SA Lowery, A Sariol, S Perlman - Cell Host & Microbe, 2021 - cell.com
COVID-19 can result in severe disease characterized by significant immunopathology that is
spurred by an exuberant, yet dysregulated, innate immune response with a poor adaptive …
spurred by an exuberant, yet dysregulated, innate immune response with a poor adaptive …
Two years into the COVID-19 pandemic: lessons learned
SJR da Silva, JCF do Nascimento… - ACS infectious …, 2022 - ACS Publications
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible
and virulent human-infecting coronavirus that emerged in late December 2019 in Wuhan …
and virulent human-infecting coronavirus that emerged in late December 2019 in Wuhan …
Persistent complement dysregulation with signs of thromboinflammation in active Long Covid
Long Covid is a debilitating condition of unknown etiology. We performed multimodal
proteomics analyses of blood serum from COVID-19 patients followed up to 12 months after …
proteomics analyses of blood serum from COVID-19 patients followed up to 12 months after …
[HTML][HTML] Immunoglobulin signature predicts risk of post-acute COVID-19 syndrome
Following acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) a significant proportion of individuals develop prolonged symptoms, a serious condition …
2) a significant proportion of individuals develop prolonged symptoms, a serious condition …
Signature of long-lived memory CD8+ T cells in acute SARS-CoV-2 infection
Immunological memory is a hallmark of adaptive immunity and facilitates an accelerated and
enhanced immune response upon re-infection with the same pathogen,. Since the outbreak …
enhanced immune response upon re-infection with the same pathogen,. Since the outbreak …
Neutrophils in COVID-19: not innocent bystanders
E McKenna, R Wubben, JM Isaza-Correa… - Frontiers in …, 2022 - frontiersin.org
Unusually for a viral infection, the immunological phenotype of severe COVID-19 is
characterised by a depleted lymphocyte and elevated neutrophil count, with the neutrophil …
characterised by a depleted lymphocyte and elevated neutrophil count, with the neutrophil …
A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene
Recently, we reported oligoadenylate synthetase 1 (OAS1) contributed to the risk of
Alzheimer's disease, by its enrichment in transcriptional networks expressed by microglia …
Alzheimer's disease, by its enrichment in transcriptional networks expressed by microglia …
Monocyte activation in systemic Covid-19 infection: Assay and rationale
FO Martinez, TW Combes, F Orsenigo, S Gordon - EBioMedicine, 2020 - thelancet.com
Mononuclear phagocytes are a widely distributed family of cells contributing to innate and
adaptive immunity. Circulating monocytes and tissue macrophages participate in all stages …
adaptive immunity. Circulating monocytes and tissue macrophages participate in all stages …
Profound dysregulation of T cell homeostasis and function in patients with severe COVID‐19
Abstract Background Coronavirus disease 2019 (COVID‐19) is caused by infection with
severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and shows a broad clinical …
severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and shows a broad clinical …
Neutrophils and COVID-19: active participants and rational therapeutic targets
J Hazeldine, JM Lord - Frontiers in immunology, 2021 - frontiersin.org
Whilst the majority of individuals infected with severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), the causative pathogen of COVID-19, experience mild to …
coronavirus 2 (SARS-CoV-2), the causative pathogen of COVID-19, experience mild to …