Reactive oxygen species are a constant threat to DNA as they modify bases with the risk of
disrupting genome function, inducing genome instability and mutation. Such risks are due to …

Reactive oxygen species (ROS) react preferentially with certain atoms to modulate functions
ranging from cell homeostasis to cell death. Molecular actions include both inhibition and …

Reactive oxygen species (ROS) are an unenviable part of aerobic life. Their steady-state
concentration is a balance between production and elimination providing certain steady …

It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …

Mitochondria can govern local concentrations of second messengers, such as reactive
oxygen species (ROS), and mitochondrial translocation to discrete subcellular regions may …

Most reactive oxygen species (ROS) are generated in cells by the mitochondrial respiratory
chain. Mitochondrial ROS production is modulated largely by the rate of electron flow …

Type 2 diabetes (T2D) is a disorder of complex genetics influenced by interactions between
susceptible genetic loci and environmental perturbations. Intrauterine growth retardation is …

In hypoxia, mitochondria-generated reactive oxygen species not only stimulate
accumulation of the transcriptional regulator of hypoxic gene expression, hypoxia inducible …

Reactive oxygen species (ROS) are now appreciated to play several important roles in a
number of biological processes and regulate cell physiology and function. ROS are a …

Modifications of DNA strands and nucleobases—both induced and accidental—are
associated with unfavorable consequences including loss or gain in genetic information and …