The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease
RH Oakley, JA Cidlowski - Journal of Allergy and Clinical Immunology, 2013 - Elsevier
Glucocorticoids are primary stress hormones necessary for life that regulate numerous
physiologic processes in an effort to maintain homeostasis. Synthetic derivatives of these …
physiologic processes in an effort to maintain homeostasis. Synthetic derivatives of these …
Checks and balances: The glucocorticoid receptor and NFĸB in good times and bad
Mutual regulation and balance between the endocrine and immune systems facilitate an
organism's stress response and are impaired following chronic stress or prolonged immune …
organism's stress response and are impaired following chronic stress or prolonged immune …
Mechanisms of brain glucocorticoid resistance in stress-induced psychopathologies
VM Merkulov, TI Merkulova, NP Bondar - Biochemistry (Moscow), 2017 - Springer
Exposure to stress activates the hypothalamic–pituitary–adrenal axis and leads to increased
levels of glucocorticoid (GC) hormones. Prolonged elevation of GC levels causes neuronal …
levels of glucocorticoid (GC) hormones. Prolonged elevation of GC levels causes neuronal …
Prefrontal cortical trkB, glucocorticoids, and their interactions in stress and developmental contexts
ET Barfield, SL Gourley - Neuroscience & Biobehavioral Reviews, 2018 - Elsevier
The tropomyosin/tyrosine receptor kinase B (trkB) and glucocorticoid receptor (GR) regulate
neuron structure and function and the hormonal stress response. Meanwhile, disruption of …
neuron structure and function and the hormonal stress response. Meanwhile, disruption of …
[PDF][PDF] Pharmacological modulation of HPA axis in depression–new avenues for potential therapeutic benefits
PHARMACOLOGICAL MODULATION OF HPA AXIS IN DEPRESSION – NEW AVENUES FOR
POTENTIAL THERAPEUTIC BENEFITS Page 1 299 Psychiatria Danubina, 2013; Vol. 25, No. 3 …
POTENTIAL THERAPEUTIC BENEFITS Page 1 299 Psychiatria Danubina, 2013; Vol. 25, No. 3 …
From feedback loop transitions to biomarkers in the psycho-immune-neuroendocrine network: Detecting the critical transition from health to major depression
NJC Stapelberg, R Pratt, DL Neumann… - Neuroscience & …, 2018 - Elsevier
Background Biological pathways underlying major depressive disorder (MDD) can be
viewed as systems biology networks. The psycho-immune-neuroendocrine (PINE) network …
viewed as systems biology networks. The psycho-immune-neuroendocrine (PINE) network …
Inhibition of JNK ameliorates depressive-like behaviors and reduces the activation of pro-inflammatory cytokines and the phosphorylation of glucocorticoid receptors …
J Zhang, W Lin, M Tang, Y Zhao, K Zhang… - …, 2020 - Elsevier
Depression is associated with immune dysregulation and the aberrant activity of the
hypothalamic-pituitary-adrenal (HPA) axis. However, the neurobiological molecular …
hypothalamic-pituitary-adrenal (HPA) axis. However, the neurobiological molecular …
Timing and crosstalk of glucocorticoid signaling with cytokines, neurotransmitters and growth factors
M Arango-Lievano, F Jeanneteau - Pharmacological research, 2016 - Elsevier
Glucocorticoid actions are tailored to the organs and cells responding thanks to complex
integration with ongoing signaling mediated by cytokines, hormones, neurotransmitters, and …
integration with ongoing signaling mediated by cytokines, hormones, neurotransmitters, and …
Novel antidepressant‐like activity of propolis extract mediated by enhanced glucocorticoid receptor function in the hippocampus
MS Lee, YH Kim, WS Park, WG Ahn… - Evidence‐Based …, 2013 - Wiley Online Library
Propolis is a natural product made by honeybees that has been widely used in folk medicine
with a broad spectrum of biological activities. To investigate the antidepressant‐like activity …
with a broad spectrum of biological activities. To investigate the antidepressant‐like activity …
Lymphocyte levels of redox-sensitive transcription factors and antioxidative enzymes as indicators of pro-oxidative state in depressive patients
Background: Oxidative stress is reliably observed in major depressive disorder (MDD).
However, molecular data on the principal cellular redox-sensitive transcriptional factors and …
However, molecular data on the principal cellular redox-sensitive transcriptional factors and …