The advent of the knowledge on human genetics, by the identification of disease-associated
variants, culminated in the understanding of human variability. With the genetic knowledge …

A plethora of databases exist online that can assist in in silico chemical or drug safety
assessment. However, a systematic review and grouping of databases, based on purpose …

In a clinical trial, people with the same disease can show different responses after treatment
with the same drug and exactly under the same conditions. Some of them may improve …

Today, there is a collection of a tremendous amount of bio-data because of the
computerized applications worldwide. Therefore, scholars have been encouraged to …

Inflammatory Bowel disease (IBD) is a widespread pathological condition with clinical
heterogeneity and with different levels of severity. Although IBD usually occurs in young …

Highlights•Bioinformatics as the leading scientific domain in drug discovery.•Updated list of
publically available bioinformatics resources.•Integrative omics that facilitate the rational …

The global control of tuberculosis (TB) remains a great challenge from the standpoint of
diagnosis, detection of drug resistance, and treatment. Major serodiagnostic limitations …

Past decades have seen much effort devoted to the tool development for biomacromolecule
structural visualization and analysis. In recent years, we have witnessed tremendous …

Gene therapy has been a long lasting goal for scientists, and there are many optimal
methods and tools to correct disease-causing mutations in humans. Recently, the Clustered …

Genetics is a dynamic and rapidly advancing field of biology that has found applications in
all dimensions of human life. Breakthrough genetic discoveries are reported regularly in all …