[HTML][HTML] Antibiotics from insect-associated actinobacteria
AA Baranova, YV Zakalyukina, AA Ovcharenko… - Biology, 2022 - mdpi.com
Simple Summary Actinobacteria remain a key source for antibiotic discovery, and the current
antimicrobial resistance crisis is becoming a driving force for actinobacteria research. Insect …
antimicrobial resistance crisis is becoming a driving force for actinobacteria research. Insect …
[HTML][HTML] Actinomycetes associated with hymenopteran insects: a promising source of bioactive natural products
U Diarra, T Osborne-Naikatini… - Frontiers in Microbiology, 2024 - frontiersin.org
In recent years, the insect microbiome has become the focus of many actinomycete
researchers in their search for novel bioactive compounds with members of the order …
researchers in their search for novel bioactive compounds with members of the order …
Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel
IA Osterman, M Wieland, TP Maviza… - Nature chemical …, 2020 - nature.com
The increase in multi-drug resistant pathogenic bacteria is making our current arsenal of
clinically used antibiotics obsolete, highlighting the urgent need for new lead compounds …
clinically used antibiotics obsolete, highlighting the urgent need for new lead compounds …
[HTML][HTML] Mechanism-based approach to new antibiotic producers screening among actinomycetes in the course of the citizen science project
IA Volynkina, YV Zakalyukina, VA Alferova, AR Belik… - Antibiotics, 2022 - mdpi.com
Since the discovery of streptomycin, actinomycetes have been a useful source for new
antibiotics, but there have been diminishing rates of new finds since the 1960s. The …
antibiotics, but there have been diminishing rates of new finds since the 1960s. The …
[HTML][HTML] Conjugates of chloramphenicol amine and berberine as antimicrobial agents
JA Pavlova, AG Tereshchenkov, PA Nazarov… - Antibiotics, 2022 - mdpi.com
In order to obtain antimicrobial compounds with improved properties, new conjugates
comprising two different biologically active agents within a single chimeric molecule based …
comprising two different biologically active agents within a single chimeric molecule based …
[HTML][HTML] Triphenilphosphonium analogs of chloramphenicol as dual-acting antimicrobial and antiproliferating agents
JA Pavlova, ZZ Khairullina, AG Tereshchenkov… - Antibiotics, 2021 - mdpi.com
In the current work, in continuation of our recent research, we synthesized and studied new
chimeric compounds, including the ribosome-targeting antibiotic chloramphenicol (CHL) …
chimeric compounds, including the ribosome-targeting antibiotic chloramphenicol (CHL) …
Pharmacological potential of ants and their symbionts–a review
Abstract Ants (Hymenoptera: Formicidae) play an important role in the pharmacological and
food industry due to their therapeutic and nutritional properties. Being the most abundant …
food industry due to their therapeutic and nutritional properties. Being the most abundant …
[HTML][HTML] Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by Northern …
A Sarmiento-Vizcaíno, J Martín, FJ Ortiz-López… - Frontiers in …, 2022 - frontiersin.org
Actinobacteria, mostly Streptomyces species, are the main source of natural products
essential in medicine. While the majority of producer microorganisms of secondary …
essential in medicine. While the majority of producer microorganisms of secondary …
Insights into the molecular mechanism of translation inhibition by the ribosome-targeting antibiotic thermorubin
MN Paranjpe, VI Marina, AA Grachev… - Nucleic acids …, 2023 - academic.oup.com
Thermorubin (THR) is an aromatic anthracenopyranone antibiotic active against both Gram-
positive and Gram-negative bacteria. It is known to bind to the 70S ribosome at the …
positive and Gram-negative bacteria. It is known to bind to the 70S ribosome at the …
[HTML][HTML] Binding and action of triphenylphosphonium analog of chloramphenicol upon the bacterial ribosome
CW Chen, JA Pavlova, DA Lukianov… - Antibiotics, 2021 - mdpi.com
Chloramphenicol (CHL) is a ribosome-targeting antibiotic that binds to the peptidyl
transferase center (PTC) of the bacterial ribosome and inhibits peptide bond formation. As …
transferase center (PTC) of the bacterial ribosome and inhibits peptide bond formation. As …