Simple Summary Actinobacteria remain a key source for antibiotic discovery, and the current
antimicrobial resistance crisis is becoming a driving force for actinobacteria research. Insect …

In recent years, the insect microbiome has become the focus of many actinomycete
researchers in their search for novel bioactive compounds with members of the order …

The increase in multi-drug resistant pathogenic bacteria is making our current arsenal of
clinically used antibiotics obsolete, highlighting the urgent need for new lead compounds …

Since the discovery of streptomycin, actinomycetes have been a useful source for new
antibiotics, but there have been diminishing rates of new finds since the 1960s. The …

In order to obtain antimicrobial compounds with improved properties, new conjugates
comprising two different biologically active agents within a single chimeric molecule based …

In the current work, in continuation of our recent research, we synthesized and studied new
chimeric compounds, including the ribosome-targeting antibiotic chloramphenicol (CHL) …

Abstract Ants (Hymenoptera: Formicidae) play an important role in the pharmacological and
food industry due to their therapeutic and nutritional properties. Being the most abundant …

Actinobacteria, mostly Streptomyces species, are the main source of natural products
essential in medicine. While the majority of producer microorganisms of secondary …

Thermorubin (THR) is an aromatic anthracenopyranone antibiotic active against both Gram-
positive and Gram-negative bacteria. It is known to bind to the 70S ribosome at the …

Chloramphenicol (CHL) is a ribosome-targeting antibiotic that binds to the peptidyl
transferase center (PTC) of the bacterial ribosome and inhibits peptide bond formation. As …