Autophagy is fundamental to the maintenance of intracellular homeostasis in virtually all
human cells. Accordingly, defective autophagy predisposes healthy cells to undergoing …

Over the past two decades, the natural history of multiple myeloma (MM) has evolved
dramatically, owing primarily to novel agents targeting MM in the bone marrow …

Abstract Background MicroRNA-155 (miR-155) is closely associated with diabetic peripheral
neuropathy (DPN). Astragaloside IV (AST) is a significant extract of Astragalus …

This study reviews the molecular mechanism of exercise-induced autophagy/mitophagy and
its possible mechanism in delaying motor symptoms progressivity in Parkinson's disease …

Multiple myeloma (MM) is a plasma cell neoplasm characterized by an abnormal
proliferation of clonal, terminally differentiated B lymphocytes. Current approaches for the …

Simple Summary Advances in treatment, especially with novel drugs, have dramatically
improved the survival of multiple myeloma (MM) patients recently. However, frequent …

Haematopoiesis is a tightly orchestrated process where a pool of hematopoietic stem and
progenitor cells (HSPCs) with high self-renewal potential can give rise to both lymphoid and …

Simple Summary Autophagy is a dynamic and tightly regulated process that seems to have
dual effects in cancer. In some contexts, it can induce carcinogenesis and promote cancer …

Beclin1 is an important autophagy‑related protein, which is involved in both autophagy and
apoptosis. In recent years, the antitumor effect of Beclin1 has received increased attention …

Autophagy plays an important role in plasma cell ontogeny and in the pathophysiology of
multiple myeloma. Autophagy is usually considered a pro-survival mechanism, and …