The pharmacokinetic properties of drugs are closely related to their pharmacological
efficacy. The kinetics of ivermectin are characterised, in general terms, by a slow absorption …

Ivermectin is considered to be a wonder drug due to its broad-spectrum antiparasitic activity
against both ectoparasites and endoparasites (under class of endectocide) and has multiple …

Abstract P-Glycoprotein (P-GP) is a transport protein that participates in the mechanism of
active secretion of different molecules from the bloodstream to the gastrointestinal tract. The …

The high level of resistance to the macrocyclic lactones has encouraged the search for
strategies to optimize their potential as antiparasitic agents. There is a need for pharmaco …

The macrocyclic lactones have pharmacokinetic properties which enhance their use against
endo-and ectoparasites in animals and man. The most consistent physico-chemical feature …

The effects of avermectin [ivermectin (IVM) and doramectin (DRM)] faecal residues on dung
colonization and degradation by invertebrates were evaluated during late spring in the east …

Ivermectin (IVM) is a broad-spectrum antiparasitic drug extensively used in veterinary
medicine. The composition of the pharmaceutical preparation affects IVM absorption and its …

The plasma concentration profiles of four randomly chosen ivermectin (IVM) generic
formulations (IVM G1–G4) were compared after their subcutaneous (SC) administration to …

The in vivo co-administration of ivermectin (IVM) with P-glycoprotein (P-gp) modulator
agents has been shown to enhance its systemic availability. However, there is no sufficient …

Background Ivermectin is one of the first, safe, broad-spectrum avermectin class of
antiparasitic agent, widely used to control parasitic growth in livestock. Ivermectin being …