Exploring the next generation of antibody–drug conjugates
Antibody–drug conjugates (ADCs) are a promising cancer treatment modality that enables
the selective delivery of highly cytotoxic payloads to tumours. However, realizing the full …
the selective delivery of highly cytotoxic payloads to tumours. However, realizing the full …
[HTML][HTML] Current approaches of nanomedicines in the market and various stage of clinical translation
X Shan, X Gong, J Li, J Wen, Y Li, Z Zhang - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Compared with traditional drug therapy, nanomedicines exhibit intriguing biological features
to increase therapeutic efficiency, reduce toxicity and achieve targeting delivery. This review …
to increase therapeutic efficiency, reduce toxicity and achieve targeting delivery. This review …
The evolving landscape of antibody–drug conjugates: In depth analysis of recent research progress
Antibody–drug conjugates (ADCs) are targeted immunoconjugate constructs that integrate
the potency of cytotoxic drugs with the selectivity of monoclonal antibodies, minimizing …
the potency of cytotoxic drugs with the selectivity of monoclonal antibodies, minimizing …
Claudin18. 2 is a novel molecular biomarker for tumor-targeted immunotherapy
W Cao, H Xing, Y Li, W Tian, Y Song, Z Jiang, J Yu - Biomarker Research, 2022 - Springer
Abstract The claudin18. 2 (CLDN18. 2) protein, an isoform of claudin18, a member of the
tight junction protein family, is a highly selective biomarker with limited expression in normal …
tight junction protein family, is a highly selective biomarker with limited expression in normal …
ADCdb: the database of antibody–drug conjugates
L Shen, X Sun, Z Chen, Y Guo, Z Shen… - Nucleic Acids …, 2024 - academic.oup.com
Antibody-drug conjugates (ADCs) are a class of innovative biopharmaceutical drugs, which,
via their antibody (mAb) component, deliver and release their potent warhead (aka. payload) …
via their antibody (mAb) component, deliver and release their potent warhead (aka. payload) …
New treatment strategies for advanced-stage gastrointestinal stromal tumours
LR Klug, HM Khosroyani, JD Kent… - Nature reviews Clinical …, 2022 - nature.com
When gastrointestinal stromal tumour (GIST), the most common form of sarcoma, was first
recognized as a distinct pathological entity in the 1990s, patients with advanced-stage …
recognized as a distinct pathological entity in the 1990s, patients with advanced-stage …
[HTML][HTML] Targeting breast cancer stem cells
The potential roles of breast cancer stem cells (BCSCs) in tumor initiation and recurrence
have been recognized for many decades. Due to their strong capacity for self-renewal and …
have been recognized for many decades. Due to their strong capacity for self-renewal and …
Multifunctional nanoparticle-mediated combining therapy for human diseases
X Li, X Peng, M Zoulikha, GF Boafo, KT Magar… - … and Targeted Therapy, 2024 - nature.com
Combining existing drug therapy is essential in developing new therapeutic agents in
disease prevention and treatment. In preclinical investigations, combined effect of certain …
disease prevention and treatment. In preclinical investigations, combined effect of certain …
Novel ADCs and strategies to overcome resistance to anti-HER2 ADCs
Simple Summary A proportion of breast tumors bear the oncogenic transmembrane tyrosine
kinase protein HER2. Even though therapies that target HER2 have changed the prognosis …
kinase protein HER2. Even though therapies that target HER2 have changed the prognosis …
[HTML][HTML] The evolving landscape of antibody-drug conjugates in gynecologic cancers
A Tolcher, E Hamilton, RL Coleman - Cancer treatment reviews, 2023 - Elsevier
Despite significant advances in the treatment of cervical, ovarian, and uterine cancers with
the approvals of checkpoint and PARP inhibitors into standard treatment, patients with …
the approvals of checkpoint and PARP inhibitors into standard treatment, patients with …