Apoptosis or programmed cell death is an active form of cell death which is essential for
tissue homeostasis. Many proteins are involved in the molecular signal transduction of …

SUMMARY 1 Photodynamic therapy is an established modality for the treatment of solid
tumours and other accessible lesions. Although the concept and practice of combining light …

Ubiquitously expressed μ-and m-calpain proteases are implicated in development and
apoptosis. They consist of 80-kDa catalytic subunits encoded by the capn1 and capn2 …

Caffeic acid phenethyl ester (CAPE), an active component of propolis, has many biological
and pharmacological activities including antioxidation and tumor cell cytotoxicity. We …

Introduction Inhibitors of cyclo-oxygenase (COX)-2 are being extensively studied as
anticancer agents. In the present study we evaluated the mechanisms by which a highly …

We earlier demonstrated that gallic acid (3, 4, 5-trihydroxybenzoic acid) induced apoptosis
in promyelocytic leukemia HL-60RG cells, which was inhibited by catalase and intracellular …

MATERIALS AND METHODS Costunolide and Other Reagents Dried stem bark (2.4 kg) of
Magnolia sieboldii was pulverized and extracted continuously in a Soxleht apparatus with …

Bcl-2 has been shown to promote survival of cancer cells by maintaining a slight pro-oxidant
state through elevated mitochondrial respiration during basal conditions. On oxidative …

Inhibition of the mitochondrial pathway of apoptosis has been implicated as a mechanism
contributing to carcinogenesis. Chronic inflammation, which is accompanied by activation of …

Absence of the proapoptotic protein Bax renders tumor cells resistant to drug-induced
apoptosis. We have shown that hydrogen peroxide (H2O2)-mediated cytosolic acidification …