The review compiles artificial cascades involving enzymes with a focus on the last 10 years.
A cascade is defined as the combination of at least two reaction steps in a single reaction …

In the past decade, the asymmetric synthesis of chiral nonracemic isoquinoline alkaloids, a
family of natural products showing a wide range of structural diversity and biological and …

Berberine is an extensively used pharmaceutical benzylisoquinoline alkaloid (BIA) derived
from plants. Microbial manufacturing has emerged as a promising approach to source …

Enzymes exercise impeccable control over chemoselectivity, site selectivity and
stereoselectivity in reactions they mediate, such that we have witnessed a surge in the …

This review provides an overview of oxidases that utilise a flavin cofactor for catalysis. This
class of oxidative flavoenzymes has shown to harbour a large number of biotechnologically …

This account focuses on the application of ω-transaminases, lyases, and oxidases for the
preparation of amines considering mainly work from our own lab. Examples are given to …

Deracemization, that is, the transformation of a racemate into a single product enantiomer
with theoretically 100% conversion and 100% ee, is an appealing but also challenging …

Alkaloids are not only one of the most intensively studied classes of natural products, their
wide spectrum of pharmacological activities also makes them indispensable drug …

Traditional methods of chemical synthesis of alkaloids exhibit various problems such as lack
of enantioselectivity, the use of toxic chemical and intermediates, and multiple numbers of …

Cyclic amines such as pyrrolidine undergo redox‐annulations with 2‐formylaryl malonates.
Concurrent oxidative amine α‐C H bond functionalization and reductive N‐alkylation …