Genomic surveillance for antimicrobial resistance—a One Health perspective

SP Djordjevic, VM Jarocki, T Seemann… - Nature Reviews …, 2024 - nature.com
Antimicrobial resistance (AMR)—the ability of microorganisms to adapt and survive under
diverse chemical selection pressures—is influenced by complex interactions between …

Challenges and opportunities in sharing microbiome data and analyses

C Huttenhower, RD Finn, AC McHardy - Nature Microbiology, 2023 - nature.com
Microbiome data, metadata and analytical workflows have become 'big'in terms of volume
and complexity. Although the infrastructure and technologies to share data have been …

Metagenomics of Parkinson's disease implicates the gut microbiome in multiple disease mechanisms

ZD Wallen, A Demirkan, G Twa, G Cohen… - Nature …, 2022 - nature.com
Parkinson's disease (PD) may start in the gut and spread to the brain. To investigate the role
of gut microbiome, we conducted a large-scale study, at high taxonomic resolution, using …

Standardized multi-omics of Earth's microbiomes reveals microbial and metabolite diversity

JP Shaffer, LF Nothias, LR Thompson, JG Sanders… - Nature …, 2022 - nature.com
Despite advances in sequencing, lack of standardization makes comparisons across studies
challenging and hampers insights into the structure and function of microbial communities …

[HTML][HTML] Biosynthetic potential of the global ocean microbiome

L Paoli, HJ Ruscheweyh, CC Forneris, F Hubrich… - Nature, 2022 - nature.com
Natural microbial communities are phylogenetically and metabolically diverse. In addition to
underexplored organismal groups, this diversity encompasses a rich discovery potential for …

A deep siamese neural network improves metagenome-assembled genomes in microbiome datasets across different environments

S Pan, C Zhu, XM Zhao, LP Coelho - Nature communications, 2022 - nature.com
Metagenomic binning is the step in building metagenome-assembled genomes (MAGs)
when sequences predicted to originate from the same genome are automatically grouped …

<? mode longmeta?> SPIRE: a Searchable, Planetary-scale mIcrobiome REsource

TSB Schmidt, A Fullam, P Ferretti, A Orakov… - Nucleic Acids …, 2024 - academic.oup.com
Meta'omic data on microbial diversity and function accrue exponentially in public
repositories, but derived information is often siloed according to data type, study or sampled …

Emu: species-level microbial community profiling of full-length 16S rRNA Oxford Nanopore sequencing data

KD Curry, Q Wang, MG Nute, A Tyshaieva, E Reeves… - Nature …, 2022 - nature.com
Abstract 16S ribosomal RNA-based analysis is the established standard for elucidating the
composition of microbial communities. While short-read 16S rRNA analyses are largely …

[HTML][HTML] A review of computational tools for generating metagenome-assembled genomes from metagenomic sequencing data

C Yang, D Chowdhury, Z Zhang, WK Cheung… - Computational and …, 2021 - Elsevier
Metagenomic sequencing provides a culture-independent avenue to investigate the
complex microbial communities by constructing metagenome-assembled genomes (MAGs) …

Benchmarking second and third-generation sequencing platforms for microbial metagenomics

V Meslier, B Quinquis, K Da Silva, F Plaza Oñate… - Scientific Data, 2022 - nature.com
Shotgun metagenomic sequencing is a common approach for studying the taxonomic
diversity and metabolic potential of complex microbial communities. Current methods …