Cells, both of prokaryotic and eukaryotic origin, have developed dedicated molecular
mechanisms to tightly control expression levels of their genes where the specific …

It is widely accepted that the growing demand for recombinant therapeutic proteins has led
to the expansion of the biopharmaceutical industry and the development of strategies to …

Ongoing research efforts to identify potent regulatory sequences that deliver robust and
sustained transgene expression are critical for Chinese hamster ovary (CHO) cell line …

This is the first report about flaxseed protein hydrolysates applied as media supplements in
CHO cell culture. The hydrolysates were produced by three separate enzymatic digestions …

The complex structure of monoclonal antibodies (mAbs) expressed in Chinese hamster
ovary (CHO) cells may result in the accumulation of unfolded proteins, triggering …

We previously demonstrated that increased monoclonal antibody productivity in
dihydrofolate reductase (DHFR)-amplified CHO cells correlates with phosphorylated …

CHO cells are extensively employed in biological drug industry to manufacture therapeutic
proteins. Nevertheless, production of biopharmaceuticals faces obstacles such as limited …

Chinese hamster ovary (CHO) cells are the most popular mammalian cell factories for the
production of glycosylated biopharmaceuticals. To further increase titer and productivity and …

Aerobic glycolysis and its by‐product lactate accumulation are usually associated with
adverse culture phenotypes such as poor cell viability and productivity. Due to the lack of …

The establishment of cell lines with a high protein production is the most crucial objective in
the field of biopharmaceuticals. To this end, efforts have been made to increase transgene …