The mechanistic link between selective vulnerability of the locus coeruleus and neurodegeneration in Alzheimer's disease
Alzheimer's disease (AD) is neuropathologically characterized by the intracellular
accumulation of hyperphosphorylated tau and the extracellular deposition of amyloid-β …
accumulation of hyperphosphorylated tau and the extracellular deposition of amyloid-β …
Physiology, signaling, and pharmacology of galanin peptides and receptors: three decades of emerging diversity
R Lang, AL Gundlach, FE Holmes, SA Hobson… - Pharmacological …, 2015 - ASPET
Galanin was first identified 30 years ago as a" classic neuropeptide," with actions primarily
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …
The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease
R Lang, AL Gundlach, B Kofler - Pharmacology & therapeutics, 2007 - Elsevier
The galanin peptide family consists of the “parental” galanin, galanin-message-associated
peptide (GMAP) which derives from the same peptide precursor gene product as galanin …
peptide (GMAP) which derives from the same peptide precursor gene product as galanin …
Norepinephrine: the redheaded stepchild of Parkinson's disease
KS Rommelfanger, D Weinshenker - Biochemical pharmacology, 2007 - Elsevier
Parkinson's disease (PD) affects approximately 1% of the world's aging population. Despite
its prevalence and rigorous research in both humans and animal models, the etiology …
its prevalence and rigorous research in both humans and animal models, the etiology …
An overview of brain‐derived neurotrophic factor and implications for excitotoxic vulnerability in the hippocampus
PS Murray, PV Holmes - International journal of peptides, 2011 - Wiley Online Library
The present paper examines the nature and function of brain‐derived neurotrophic factor
(BDNF) in the hippocampal formation and the consequences of changes in its expression …
(BDNF) in the hippocampal formation and the consequences of changes in its expression …
Noradrenaline activation of neurotrophic pathways protects against neuronal amyloid toxicity
J. Neurochem.(2010) 113, 649–660. Abstract Degeneration of locus coeruleus (LC)
noradrenergic forebrain projection neurons is an early feature of Alzheimer's disease. The …
noradrenergic forebrain projection neurons is an early feature of Alzheimer's disease. The …
[HTML][HTML] VEGF-A165b is an endogenous neuroprotective splice isoform of vascular endothelial growth factor A in vivo and in vitro
Vascular endothelial growth factor (VEGF) A is generated as two isoform families by
alternative RNA splicing, represented by VEGF-A 165 a and VEGF-A 165 b. These isoforms …
alternative RNA splicing, represented by VEGF-A 165 a and VEGF-A 165 b. These isoforms …
Epileptogenesis and chronic seizures in a mouse model of temporal lobe epilepsy are associated with distinct EEG patterns and selective neurochemical alterations in …
D Arabadzisz, K Antal, F Parpan, Z Emri… - Experimental neurology, 2005 - Elsevier
Major aspects of temporal lobe epilepsy (TLE) can be reproduced in mice following a
unilateral injection of kainic acid into the dorsal hippocampus. This treatment induces a non …
unilateral injection of kainic acid into the dorsal hippocampus. This treatment induces a non …
Brain galanin system genes interact with life stresses in depression-related phenotypes
Galanin is a stress-inducible neuropeptide and cotransmitter in serotonin and
norepinephrine neurons with a possible role in stress-related disorders. Here we report that …
norepinephrine neurons with a possible role in stress-related disorders. Here we report that …
[PDF][PDF] The neuropeptide galanin is required for homeostatic rebound sleep following increased neuronal activity
Sleep pressure increases during wake and dissipates during sleep, but the molecules and
neurons that measure homeostatic sleep pressure remain poorly understood. We present a …
neurons that measure homeostatic sleep pressure remain poorly understood. We present a …