The pleiotropic spectrum of proximal 16p11. 2 CNVs

C Auwerx, Z Kutalik, A Reymond - The American Journal of Human …, 2024 - cell.com
Recurrent genomic rearrangements at 16p11. 2 BP4-5 represent one of the most common
causes of genomic disorders. Originally associated with increased risk for autism spectrum …

Highly demarcated structural alterations in the brain and impaired social incentive learning in Tbx1 heterozygous mice

T Hiramoto, A Sumiyoshi, R Kato, T Yamauchi… - Molecular …, 2024 - nature.com
Copy number variants (CNVs) are robustly associated with psychiatric disorders and
changes in brain structures. However, because CNVs contain many genes, the precise gene …

Effects of gene dosage and development on subcortical nuclei volumes in individuals with 22q11. 2 copy number variations

CH Schleifer, KP O'Hora, H Fung, J Xu… - …, 2024 - nature.com
Abstract The 22q11. 2 locus contains genes critical for brain development. Reciprocal Copy
Number Variations (CNVs) at this locus impact risk for neurodevelopmental and psychiatric …

Subcortical anatomy in neurogenetic disorders: new findings and future questions

K Wagstyl, A Raznahan - American Journal of Psychiatry, 2023 - Am Psychiatric Assoc
Psychiatric disorders are currently classified according to behaviorally defined diagnostic
criteria. These categories are invaluable for formalizing a reproducible taxonomy, providing …

Seeking new solutions addressing structural racism, childhood trauma, suicidal behaviors across sexual orientations, and postpartum depression

NH Kalin - American journal of psychiatry, 2023 - Am Psychiatric Assoc
This issue of the Journal presents a wide range of interesting topics that are relevant to
diversity and discrimination in psychiatry, PTSD in youth, the genetic underpinnings of …

High-risk neuropsychiatric copy number variants are associated with convergent transcriptomic changes in human brain cells

G Dugan, N Akula, S Marenco, P Auluck, A Raznahan… - bioRxiv, 2024 - biorxiv.org
Large, recurrent copy number variants (CNVs) are among the strongest risk factors for
neuropsychiatric conditions, contributing to multiple phenotypes with overlapping psychiatric …

Large-Scale Neuroimaging of Mental Illness

CRK Ching, MJY Kang, PM Thompson - 2024 - Springer
Neuroimaging has provided important insights into the brain variations related to mental
illness. Inconsistencies in prior studies, however, call for methods that lead to more …

Population Neuroscience: Principles and Advances

T Paus - 2024 - Springer
In population neuroscience, three disciplines come together to advance our knowledge of
factors that shape the human brain: neuroscience, genetics, and epidemiology (Paus …

Mapping Brain Development with Magnetic Resonance Imaging in Clinical and Genetic Neuropsychiatric Risk Syndromes

CH Schleifer - 2024 - search.proquest.com
Neurodevelopmental syndromes such as schizophrenia and autism are driven by a
confluence of genetic and environmental risk factors leading to differences in brain …