[HTML][HTML] Role of oxidative stress in the pathogenesis of non-alcoholic fatty liver disease: implications for prevention and therapy

JC Arroyave-Ospina, Z Wu, Y Geng, H Moshage - Antioxidants, 2021 - mdpi.com
Oxidative stress (OxS) is considered a major factor in the pathophysiology of inflammatory
chronic liver diseases, including non-alcoholic liver disease (NAFLD). Chronic impairment of …

Nonalcoholic Fatty Liver Disease and the Heart: JACC State-of-the-Art Review

EP Stahl, DS Dhindsa, SK Lee, PB Sandesara… - Journal of the American …, 2019 - jacc.org
Nonalcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD) are both
manifestations of end-organ damage of the metabolic syndrome. Through multiple …

Generation of expandable human pluripotent stem cell-derived hepatocyte-like liver organoids

SJ Mun, JS Ryu, MO Lee, YS Son, SJ Oh, HS Cho… - Journal of …, 2019 - Elsevier
Background & Aims The development of hepatic models capable of long-term expansion
with competent liver functionality is technically challenging in a personalized setting. Stem …

Non-alcoholic fatty liver disease and dyslipidemia: an update

N Katsiki, DP Mikhailidis, CS Mantzoros - Metabolism, 2016 - Elsevier
Non-alcoholic fatty liver (NAFLD) is the most common liver disease worldwide, progressing
from simple steatosis to necroinflammation and fibrosis (leading to non-alcoholic …

Non-alcoholic fatty liver disease and risk of cardiovascular disease

A Lonardo, S Sookoian, CJ Pirola, G Targher - Metabolism, 2016 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver
diseases worldwide, causing considerable liver-related mortality and morbidity. During the …

[HTML][HTML] mTOR: A potential new target in nonalcoholic fatty liver disease

J Feng, S Qiu, S Zhou, Y Tan, Y Bai, H Cao… - International journal of …, 2022 - mdpi.com
The global prevalence of nonalcoholic fatty liver disease (NAFLD) continues to rise, yet
effective treatments are lacking due to the complex pathogenesis of this disease. Although …

Associations between metformin use and vitamin B12 levels, anemia, and neuropathy in patients with diabetes: a meta‐analysis

W Yang, X Cai, H Wu, L Ji - Journal of diabetes, 2019 - Wiley Online Library
Background Metformin is first‐line therapy for patients with diabetes. However, it may lower
vitamin B12 concentrations, which could have hematological or neurological implications …

[HTML][HTML] Oxidative stress in non-alcoholic fatty liver disease

C Smirne, E Croce, D Di Benedetto, V Cantaluppi… - Livers, 2022 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a challenging disease caused by multiple
factors, which may partly explain why it still remains an orphan of adequate therapies. This …

Ameliorative effects and molecular mechanisms of vine tea on western diet-induced NAFLD

K Xie, X He, K Chen, K Sakao, DX Hou - Food & function, 2020 - pubs.rsc.org
Non-alcoholic fatty liver disease (NAFLD) is a disease that is prevalent worldwide, and its
prevention by dietary administration has recently been considered as an important strategy …

Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) for the management of nonalcoholic fatty liver disease (NAFLD): a systematic review

X Lv, Y Dong, L Hu, F Lu, C Zhou… - … , diabetes & metabolism, 2020 - Wiley Online Library
There are no licensed drugs for nonalcoholic fatty liver disease (NAFLD), and there is a lack
of consensus on the best outcome measures for controlled trials. This systematic review …