Carbohydrates—namely glycans—decorate every cell in the human body and most secreted
proteins. Advances in genomics, glycoproteomics and tools from chemical biology have …

One decade ago, vascular endothelium was commonly considered a" non-stick" lining of
blood vessels that functioned only to prevent blood coagulation and to separate the vascular …

The effector phase of an immune response involves the secretion of protein mediators by
antigen-stimulated T lymphocytes, which serve to recruit and activate the various responsive …

Perspectives Page 1 Perspectives Selectins Michael P. Bevilacqua and Richard M. Nelson
Howard Hughes Medical Institute, Cellular and Molecular Medicine andDepartment ofPathology …

Neutrophil research relies largely on studies with highly purified cells. Yet the isolation
procedures induce changes in surface expression of several proteins. We used a large …

Endothelial leukocyte adhesion molecule-1 (ELAM-1) is an endothelial cell adhesion
molecule that allows myeloid cells to attach to the walls of blood vessels adjacent to sites of …

Signals delivered to B cells via CD40 can synergize with those provided by other B cell
surface receptors to induce B cell proliferation and antibody class switching as well as …

The adhesion of polymorphonuclear leukocytes (PMNs) to vascular endothelial cells (EC) is
an early and fundamental event in acute inflammation. This process requires the regulated …

The adhesive interaction between circulating lymphocytes and the high endothelial venules
(HEV) of lymph nodes (LN) is mediated by lymphocyte L-selectin, a member of the selectin …

The scrapie agent protein (Sp33-37 or PrPSC) is the disease-associated isoform of a normal
cellular membrane protein (Cp33-37 or PrPc) of unknown function. We report that normal …