Modern techniques in molecular biology, genomics, and mass spectrometry–based
proteomics have identified a large number of novel histone posttranslational modifications …

Tri‐methylation of lysine 4 on histone H3 (H3K4me3) is a near‐universal chromatin
modification at the transcription start site of active genes in eukaryotes from yeast to man …

Protein aggregation is the hallmark of neurodegeneration, but the molecular mechanisms
underlying late-onset Alzheimer's disease (AD) are unclear. Here we integrated …

Epigenetic modifications on DNA and histones regulate gene expression by modulating
chromatin accessibility to transcription machinery. Here we identify methionine as a key …

Epithelial-mesenchymal transition (EMT) is an important process triggered during cancer
metastasis. Regulation of EMT is mostly initiated by outside signalling, including TGF-β …

Several mechanisms have been proposed for histone marks to exert their functions,
including altering the physical properties of nucleosomes by neutralization of charge via …

Nucleosome assembly following DNA replication, DNA repair and gene transcription is
critical for the maintenance of genome stability and epigenetic information. Nucleosomes …

Impaired or excessive growth of endothelial cells contributes to several diseases. However,
the functional involvement of regulatory long non-coding RNAs in these processes is not …

Viral infection is commonly associated with virus-driven hijacking of host proteins. Here we
describe a novel mechanism by which influenza virus affects host cells through the …

Trimethylation of histone H3 Lys 4 (H3K4me3) is a mark of active and poised promoters. The
Set1 complex is responsible for most somatic H3K4me3 and contains the conserved subunit …