Proper regulation and management of energy, substrate diversity and quantity, as well as
macromolecular synthesis and breakdown processes, are fundamental to cellular and …

Mitochondrial dysfunction is a hallmark of many diseases. The retrograde signaling initiated
by dysfunctional mitochondria can bring about global changes in gene expression that alters …

Background & Aims De novo lipogenesis is increased in livers of patients with nonalcoholic
steatohepatitis (NASH). Acetyl-coenzyme carboxylase catalyzes the rate-limiting step in this …

Glucose is a critical component in the proinflammatory response of macrophages (MΦs).
However, the contribution of glucose transporters (GLUTs) and the mechanisms regulating …

Sarcopenia, the age-related loss of muscle mass and function, imposes a dramatic burden
on individuals and society. The development of preventive and therapeutic strategies …

As humans evolved, perhaps the two strongest selection determinants of survival were a
robust immune response able to clear bacterial, viral, and parasitic infection and an ability to …

Bacterial biofilms in the colon alter the host tissue microenvironment. A role for biofilms in
colon cancer metabolism has been suggested but to date has not been evaluated. Using …

Perturbations in metabolic pathways can cause substantial increases in plasma and tissue
concentrations of long-chain acylcarnitines (LCACs). For example, the levels of LCACs and …

Solid tumor growth and metastasis require the interaction of tumor cells with the surrounding
tissue, leading to a view of tumors as tissue-level phenomena rather than exclusively cell …

Insulin resistance may be linked to incomplete fatty acid β-oxidation and the subsequent
increase in acylcarnitine species in different tissues including skeletal muscle. It is not …