A comprehensive guide to the pharmacologic regulation of angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 entry receptor
The recent emergence of coronavirus disease-2019 (COVID-19) as a global pandemic has
prompted scientists to address an urgent need for defining mechanisms of disease …
prompted scientists to address an urgent need for defining mechanisms of disease …
[HTML][HTML] Neurological implications of COVID-19: role of redox imbalance and mitochondrial dysfunction
Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 or COVID-19 has been
declared as a pandemic disease by the World Health Organization (WHO). Globally, this …
declared as a pandemic disease by the World Health Organization (WHO). Globally, this …
NLRP3 inflammasome inhibition and M1-to-M2 microglial polarization shifting via scoparone-inhibited TLR4 axis in ovariectomy/D-galactose Alzheimer's disease rat …
WW Ibrahim, K Skalicka-Woźniak, B Budzyńska… - International …, 2023 - Elsevier
Neuroinflammation mediated by microglia activation is a critical contributor to Alzheimer's
disease (AD) pathogenesis. Dysregulated microglia polarization in terms of M1 …
disease (AD) pathogenesis. Dysregulated microglia polarization in terms of M1 …
[HTML][HTML] Carnosic acid mitigates depression-like behavior in ovariectomized mice via activation of Nrf2/HO-1 pathway
The peri-and post-menopausal periods have been described as the “window of
vulnerability” for the development of depressive symptoms that impair women activities and …
vulnerability” for the development of depressive symptoms that impair women activities and …
[HTML][HTML] Predicting potential SARS-COV-2 drugs—In depth drug database screening using deep neural network framework SSnet, classical virtual screening and …
Severe Acute Respiratory Syndrome Corona Virus 2 has altered life on a global scale. A
concerted effort from research labs around the world resulted in the identification of potential …
concerted effort from research labs around the world resulted in the identification of potential …
Boosting amygdaloid GABAergic and neurotrophic machinery via dapagliflozin-enhanced LKB1/AMPK signaling in anxious demented rats
Anxiety is a neuropsychiatric disturbance that is commonly manifested in various dementia
forms involving Alzheimer's disease (AD). The mechanisms underlying AD-associated …
forms involving Alzheimer's disease (AD). The mechanisms underlying AD-associated …
[HTML][HTML] Environmental nanoparticles, SARS-CoV-2 brain involvement, and potential acceleration of Alzheimer's and Parkinson's diseases in young urbanites …
L Calderon-Garciduenas… - Journal of …, 2020 - content.iospress.com
Alzheimer's and Parkinson's diseases (AD, PD) have a pediatric and young adult onset in
Metropolitan Mexico City (MMC). The SARS-CoV-2 neurotropic RNA virus is triggering …
Metropolitan Mexico City (MMC). The SARS-CoV-2 neurotropic RNA virus is triggering …
[HTML][HTML] Dapagliflozin as an autophagic enhancer via LKB1/AMPK/SIRT1 pathway in ovariectomized/d-galactose Alzheimer's rat model
Autophagy and mitochondrial deficits are characteristics of early phase of Alzheimer's
disease (AD). Sodium-glucose cotransporter-2 inhibitors have been nominated as a …
disease (AD). Sodium-glucose cotransporter-2 inhibitors have been nominated as a …
[HTML][HTML] Dimethyl fumarate, an approved multiple sclerosis treatment, reduces brain oxidative stress in SIV-infected rhesus macaques: Potential therapeutic …
Y Garcia-Mesa, HN Xu, P Vance, AL Gruenewald… - Antioxidants, 2021 - mdpi.com
Dimethyl fumarate (DMF), an antioxidant/anti-inflammatory drug approved for the treatment
of multiple sclerosis, induces antioxidant enzymes, in part through transcriptional …
of multiple sclerosis, induces antioxidant enzymes, in part through transcriptional …
Currently prescribed drugs in the UK that could upregulate or downregulate ACE2 in COVID-19 disease: a systematic review
Objective To review evidence on routinely prescribed drugs in the UK that could upregulate
or downregulate ACE2 and potentially affect COVID-19 disease. Design Systematic review …
or downregulate ACE2 and potentially affect COVID-19 disease. Design Systematic review …